Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage
文献类型：期刊论文
| 作者 | Cao, Shangtao1,2,4; Yu, Shengyong1,2; Chen, Yan1,2; Wang, Xiaoshan1,2,3,4; Zhou, Chunhua1,2,4; Liu, Yuting1,2; Kuang, Junqi1,2,4; Liu, He1,2,4; Li, Dongwei1,2,3,4; Ye, Jing1,2 |
| 刊名 | Journal of biological chemistry
 |
| 出版日期 | 2017-11-17 |
| 卷号 | 292期号:46页码:19122-19132 |
| ISSN号 | 0021-9258 |
| 关键词 | Cell signaling Chemical biology Hepatocyte Reprogramming Small molecule Met Endoderm progenitor cells |
| DOI | 10.1074/jbc.m117.812537 |
| 通讯作者 | Liu, jing(liu_jing@gibh.ac.cn) ; Pei, duanqing(pei_duanqing@gibh.ac.cn) |
| 英文摘要 | We report here an approach to redirecting somatic cell fate under chemically defined conditions without transcription factors. we start by converting mouse embryonic fibroblasts to epithelial-like cells with chemicals and growth factors. subsequent cell fate mapping reveals a robust induction of sox17 in the resulting epithelial-like cells that can be further reprogrammed to endodermal progenitor cells. interestingly, these cells can self-renew in vitro and further differentiate into albumin-producing hepatocytes that can rescue mice from acute liver injury. our results demonstrate a rational approach to convert mouse embryonic fibroblasts to hepatocytes and suggest that this mechanism-driven approach may be generalized for other cells. |
| WOS关键词 | PLURIPOTENT STEM-CELLS ; HUMAN IPS CELLS ; FUNCTIONAL-NEURONS ; DIRECT CONVERSION ; SOMATIC-CELLS ; DEFINED FACTORS ; SMALL MOLECULES ; GENERATION ; EXPRESSION ; INDUCTION |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| WOS记录号 | WOS:000415848000035 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374238 |
| 专题 | 计算机网络信息中心 |
| 通讯作者 | Liu, Jing; Pei, Duanqing |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Regenerat Biol, South China Inst Stem Cell Biol & Regenerat Med, Guangzhou Inst Biomed & Hlth, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Guangdong Prov Key Lab Stem Cell & Regenerat Med, South China Inst Stem Cell Biol & Regenerat Med, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 3.Chinese Acad Sci, Guangzhou Branch, Supercomp Ctr, Guangzhou 510530, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Shangtao,Yu, Shengyong,Chen, Yan,et al. Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage[J]. Journal of biological chemistry,2017,292(46):19122-19132. |
| APA | Cao, Shangtao.,Yu, Shengyong.,Chen, Yan.,Wang, Xiaoshan.,Zhou, Chunhua.,...&Pei, Duanqing.(2017).Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage.Journal of biological chemistry,292(46),19122-19132. |
| MLA | Cao, Shangtao,et al."Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage".Journal of biological chemistry 292.46(2017):19122-19132. |
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