Computational identification of a new seld-like family that may participate in sulfur metabolism in hyperthermophilic sulfur-reducing archaea
文献类型：期刊论文
| 作者 | Li,Gao-Peng1,2; Jiang,Liang3; Ni,Jia-Zuan3; Liu,Qiong3; Zhang,Yan1 |
| 刊名 | Bmc genomics
 |
| 出版日期 | 2014-10-17 |
| 卷号 | 15期号:1 |
| 关键词 | Selenium Sulfur Selenophosphate synthetase Bioinformatics Comparative genomics Archaea |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/1471-2164-15-908 |
| 通讯作者 | Zhang,yan(yanzhang01@sibs.ac.cn) |
| 英文摘要 | Abstractbackgroundselenium (se) and sulfur (s) are closely related elements that exhibit similar chemical properties. some genes related to s metabolism are also involved in se utilization in many organisms. however, the evolutionary relationship between the two utilization traits is unclear.resultsin this study, we conducted a comparative analysis of the selenophosphate synthetase (seld) family, a key protein for all known se utilization traits, in all sequenced archaea. our search showed a very limited distribution of seld and se utilization in this kingdom. interestingly, a seld-like protein was detected in two orders of crenarchaeota: sulfolobales and thermoproteales. sequence and phylogenetic analyses revealed that seld-like protein contains the same domain and conserved functional residues as those of seld, and might be involved in s metabolism in these s-reducing organisms. further genome-wide analysis of patterns of gene occurrence in different thermoproteales suggested that several genes, including sira-like, prx-like and adenylylsulfate reductase, were strongly related to seld-like gene. based on these findings, we proposed a simple model wherein seld-like may play an important role in the biosynthesis of certain thiophosphate compound.conclusionsour data suggest novel genes involved in s metabolism in hyperthermophilic s-reducing archaea, and may provide a new window for understanding the complex relationship between se and s metabolism in archaea. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/1471-2164-15-908 |
| 出版者 | BioMed Central |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374300 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang,Yan |
| 作者单位 | 1.University of Chinese Academy of Sciences; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2.University of Chinese Academy of Sciences; Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 3.Shenzhen University; College of Life Sciences |
| 推荐引用方式 GB/T 7714 | Li,Gao-Peng,Jiang,Liang,Ni,Jia-Zuan,et al. Computational identification of a new seld-like family that may participate in sulfur metabolism in hyperthermophilic sulfur-reducing archaea[J]. Bmc genomics,2014,15(1). |
| APA | Li,Gao-Peng,Jiang,Liang,Ni,Jia-Zuan,Liu,Qiong,&Zhang,Yan.(2014).Computational identification of a new seld-like family that may participate in sulfur metabolism in hyperthermophilic sulfur-reducing archaea.Bmc genomics,15(1). |
| MLA | Li,Gao-Peng,et al."Computational identification of a new seld-like family that may participate in sulfur metabolism in hyperthermophilic sulfur-reducing archaea".Bmc genomics 15.1(2014). |
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来源：中国科学院大学
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