Differentiated demographic histories and local adaptations between sherpas and tibetans
文献类型：期刊论文
| 作者 | Zhang,Chao1,2; Lu,Yan1; Feng,Qidi1,2; Wang,Xiaoji1,2,3; Lou,Haiyi1; Liu,Jiaojiao1,2,3; Ning,Zhilin1,2; Yuan,Kai1,2; Wang,Yuchen1,2; Zhou,Ying1,2 |
| 刊名 | Genome biology
 |
| 出版日期 | 2017-06-15 |
| 卷号 | 18期号:1 |
| ISSN号 | 1474-760X |
| 关键词 | Sherpa Tibetan Next-generation sequencing High-altitude adaptation Population history Gene flow |
| DOI | 10.1186/s13059-017-1242-y |
| 通讯作者 | Xu,shuhua(xushua@picb.ac.cn) |
| 英文摘要 | Abstractbackgroundthe genetic relationships reported by recent studies between sherpas and tibetans are controversial. to gain insights into the population history and the genetic basis of high-altitude adaptation of the two groups, we analyzed genome-wide data in 111 sherpas (tibet and nepal) and 177 tibetans (tibet and qinghai), together with available data from present-day human populations.resultssherpas and tibetans show considerable genetic differences and can be distinguished as two distinct groups, even though the divergence between them (~3200–11,300?years ago) is much later than that between han chinese and either of the two groups (~6200–16,000?years ago). sub-population structures exist in both sherpas and tibetans, corresponding to geographical or linguistic groups. differentiation of genetic variants between sherpas and tibetans associated with adaptation to either high-altitude or ultraviolet radiation were identified and validated by genotyping additional sherpa and tibetan samples.conclusionsour analyses indicate that both sherpas and tibetans are admixed populations, but the findings do not support the previous hypothesis that tibetans derive their ancestry from sherpas and han chinese. compared to tibetans, sherpas show higher levels of south asian ancestry, while tibetans show higher levels of east asian and central asian/siberian ancestry. we propose a new model to elucidate the differentiated demographic histories and local adaptations of sherpas and tibetans. |
| 语种 | 英语 |
| 出版者 | BioMed Central |
| WOS记录号 | BMC:10.1186/S13059-017-1242-Y |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374339 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu,Shuhua |
| 作者单位 | 1.Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai Institutes for Biological Sciences, CAS 2.University of Chinese Academy of Sciences 3.ShanghaiTech University; School of Life Science and Technology 4.Xizang Minzu University; Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine 5.Fudan University; State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, School of Life Sciences 6.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences 7.Collaborative Innovation Center of Genetics and Development |
| 推荐引用方式 GB/T 7714 | Zhang,Chao,Lu,Yan,Feng,Qidi,et al. Differentiated demographic histories and local adaptations between sherpas and tibetans[J]. Genome biology,2017,18(1). |
| APA | Zhang,Chao.,Lu,Yan.,Feng,Qidi.,Wang,Xiaoji.,Lou,Haiyi.,...&Xu,Shuhua.(2017).Differentiated demographic histories and local adaptations between sherpas and tibetans.Genome biology,18(1). |
| MLA | Zhang,Chao,et al."Differentiated demographic histories and local adaptations between sherpas and tibetans".Genome biology 18.1(2017). |
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来源：中国科学院大学
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