Human cytomegalovirus ie1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome
文献类型：期刊论文
| 作者 | Fang, Qianglin1,2; Chen, Ping1; Wang, Mingzhu1; Fang, Junnan1,2; Yang, Na1,2; Li, Guohong1,2; Xu, Rui-Ming1,2 |
| 刊名 | Elife
 |
| 出版日期 | 2016-01-26 |
| 卷号 | 5页码:11 |
| ISSN号 | 2050-084X |
| DOI | 10.7554/elife.11911 |
| 通讯作者 | Li, guohong(liguohong@sun5.ibp.ac.cn) ; Xu, rui-ming(rmxu@sun5.ibp.ac.cn) |
| 英文摘要 | Human cytomegalovirus (hcmv) immediate early 1 (ie1) protein associates with condensed chromatin of the host cell during mitosis. we have determined the structure of the chromatin-tethering domain (ctd) of ie1 bound to the nucleosome core particle, and discovered that the specific interaction between ie1-ctd and the h2a-h2b acidic patch impairs the compaction of higher-order chromatin structure. our results suggest that ie1 loosens up the folding of host chromatin during hcmv infections. |
| WOS关键词 | VIRAL REPLICATION ; CORE PARTICLE ; ANGSTROM RESOLUTION ; CRYSTAL-STRUCTURE ; TETHERING DOMAIN ; SIR3 STABILIZES ; BAH DOMAIN ; CHROMOSOMES ; EXPRESSION ; BINDING |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000382015900001 |
| 出版者 | ELIFE SCIENCES PUBLICATIONS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374367 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Guohong; Xu, Rui-Ming |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Qianglin,Chen, Ping,Wang, Mingzhu,et al. Human cytomegalovirus ie1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome[J]. Elife,2016,5:11. |
| APA | Fang, Qianglin.,Chen, Ping.,Wang, Mingzhu.,Fang, Junnan.,Yang, Na.,...&Xu, Rui-Ming.(2016).Human cytomegalovirus ie1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome.Elife,5,11. |
| MLA | Fang, Qianglin,et al."Human cytomegalovirus ie1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome".Elife 5(2016):11. |
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来源：中国科学院大学
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