Ultrasensitive glutathione detection based on lucigenin cathodic electrochemiluminescence in the presence of mno2 nanosheets
文献类型：期刊论文
| 作者 | Gao, Wenyue1,2; Liu, Zhongyuan1; Qi, Liming1,2; Lai, Jianping1,2; Kitte, Shimeles Addisu1,2; Xu, Guobao1 |
| 刊名 | Analytical chemistry
 |
| 出版日期 | 2016-08-02 |
| 卷号 | 88期号:15页码:7654-7659 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.6b01491 |
| 通讯作者 | Xu, guobao(guobaoxu@ciac.ac.cn) |
| 英文摘要 | Glutathione (gsh) is a crucial antioxidant produced endogenously and plays key roles in biological systems. it is vitally important to design simple, selective, and sensitive methods to sense gsh and monitor changes of gsh concentration. in this work, the cathodic electrochemiluminescence (ecl) of lucigenin in the presence of mno2 nanosheets at a glassy carbon electrode was utilized for gsh detection. gsh can reduce mno2 nanosheets into mn2+ which can obviously inhibit the ecl of lucigenin. the ecl inhibition efficiencies increase linearly with the concentrations of glutathione in the range of 10 to 2000 nm. the detection limit for gsh measurement is 3.7 nm. this proposed method is highly sensitive, selective, simple, fast, and cost-effective. moreover, this approach can detect gsh in human serum samples with excellent recoveries, which indicates its promising application under physiological conditions. |
| WOS关键词 | ELECTROGENERATED CHEMILUMINESCENCE ; SILICA NANOPARTICLES ; LITHIUM BATTERIES ; FLUORESCENT-PROBE ; QUANTUM DOTS ; ELECTRODES ; SENSOR ; NANOCOMPOSITE ; CYSTEINE ; ECL |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000380967800033 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374373 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu, Guobao |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Wenyue,Liu, Zhongyuan,Qi, Liming,et al. Ultrasensitive glutathione detection based on lucigenin cathodic electrochemiluminescence in the presence of mno2 nanosheets[J]. Analytical chemistry,2016,88(15):7654-7659. |
| APA | Gao, Wenyue,Liu, Zhongyuan,Qi, Liming,Lai, Jianping,Kitte, Shimeles Addisu,&Xu, Guobao.(2016).Ultrasensitive glutathione detection based on lucigenin cathodic electrochemiluminescence in the presence of mno2 nanosheets.Analytical chemistry,88(15),7654-7659. |
| MLA | Gao, Wenyue,et al."Ultrasensitive glutathione detection based on lucigenin cathodic electrochemiluminescence in the presence of mno2 nanosheets".Analytical chemistry 88.15(2016):7654-7659. |
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来源：中国科学院大学
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