The long noncoding rna asnr regulates degradation of bcl-2 mrna through its interaction with auf1
文献类型：期刊论文
| 作者 | Chen, Jiahui1,2,3; Liu, Lihui1,2,3; Wei, Guifeng1,2,3; Wu, Wei1,2,3; Luo, Huaxia1,2,3; Yuan, Jiao1,2,3; Luo, Jianjun1,2; Chen, Runsheng1,2,4 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2016-08-31 |
| 卷号 | 6页码:11 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep32189 |
| 通讯作者 | Chen, runsheng(rschen@ibp.ac.cn) |
| 英文摘要 | The identification and characterization of long non-coding rnas (lncrnas) in diverse biological processes has recently developed rapidly. the large amounts of non-coding rnas scale consistent with developmental complexity in eukaryotes, indicating that most of these transcripts may have functions in the regulation of biological processes and disorder in the organisms. in particular, understanding of the overall biological significance of lncrnas in cancers still remains limited. here, we found a nuclear-retained lncrna, termed lnc_asnr (apoptosis suppressing-noncoding rna), which serves as a repressor of apoptosis. lnc_asnr was discovered in a set of microarray data derived from four kinds of tumor and adjacent normal tissue samples, and displayed significant up-regulation in the tumor tissues. using an rna-pull down assay, we found that lnc_asnr interacted with the protein are/poly (u)-binding/degradation factor 1(auf1), which is reported to promote rapid degradation of the bcl-2 mrna, an inhibitor of apoptosis. lnc_asnr binds to auf1 in nucleus, decreasing the cytoplasmic proportion of auf1 which targets the b-cell lymphoma-2 (bcl-2) mrna. taken together, the overall effect of lnc_asnr expression is thus a decrease in cell apoptosis indicating that lnc_asnr may play a vital role in tumorigenesis and carcinogenesis. |
| WOS关键词 | BINDING FACTOR AUF1 ; PROSTATE-CANCER ; TUMOR-SUPPRESSOR ; NUCLEAR IMPORT ; HNRNP PROTEINS ; RICH ELEMENTS ; HUMAN-DISEASE ; AUF1/HNRNP D ; GENE ; CHROMATIN |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000382236400001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374402 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Runsheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Beijing Key Lab Noncoding RNA, Inst Biophys, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.RNCB, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jiahui,Liu, Lihui,Wei, Guifeng,et al. The long noncoding rna asnr regulates degradation of bcl-2 mrna through its interaction with auf1[J]. Scientific reports,2016,6:11. |
| APA | Chen, Jiahui.,Liu, Lihui.,Wei, Guifeng.,Wu, Wei.,Luo, Huaxia.,...&Chen, Runsheng.(2016).The long noncoding rna asnr regulates degradation of bcl-2 mrna through its interaction with auf1.Scientific reports,6,11. |
| MLA | Chen, Jiahui,et al."The long noncoding rna asnr regulates degradation of bcl-2 mrna through its interaction with auf1".Scientific reports 6(2016):11. |
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来源：中国科学院大学
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