A novel function of hepatic fog2 in insulin sensitivity and lipid metabolism through ppar alpha
文献类型：期刊论文
| 作者 | Guo, Yajie; Yu, Junjie; Deng, Jiali; Liu, Bin; Xiao, Yuzhong; Li, Kai; Xiao, Fei; Yuan, Feixiang; Liu, Yong; Chen, Shanghai |
| 刊名 | Diabetes
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 65期号:8页码:2151-2163 |
| ISSN号 | 0012-1797 |
| DOI | 10.2337/db15-1565 |
| 通讯作者 | Guo, feifan(ffguo@sibs.ac.cn) |
| 英文摘要 | Friend of gata 2 (fog2) is a transcriptional cofactor involved mostly in cardiac function. the aim of this study was to investigate the role of hepatic fog2 in insulin sensitivity and lipid accumulation. fog2 overexpression by adenovirus-expressing fog2 (ad-fog2) significantly attenuates insulin signaling in hepatocytes in vitro. opposite effects were observed when fog2 was knocked down through adenovirus-expressing small hairpin rna for fog2 (ad-shfog2). furthermore, fog2 knockdown by ad-shfog2 ameliorated insulin resistance in leptin receptor-mutated (db/db) mice, and fog2 overexpression by ad-fog2 attenuated insulin sensitivity in c57bl/6j wild-type (wt) mice. in addition, ad-fog2 reduced, whereas ad-shfog2 promoted, hepatic triglyceride (tg) accumulation in wt mice under fed or fasted conditions, which was associated with increased or decreased hepatic peroxisome proliferator-activated receptor alpha (ppar alpha) expression, respectively. moreover, the improved insulin sensitivity and increased hepatic tg accumulation by ad-shfog2 were largely reversed by adenovirus-expressing ppar alpha (ad-ppar alpha) in wt mice. finally, we generated fog2 liver-specific knockout mice and found that they exhibit enhanced insulin sensitivity and elevated hepatic tg accumulation, which were also reversed by ad-ppar alpha. taken together, the results demonstrate a novel function of hepatic fog2 in insulin sensitivity and lipid metabolism through ppar alpha. |
| WOS关键词 | RECEPTOR (PPAR)-ALPHA ACTIVATION ; GATA TRANSCRIPTION FACTORS ; FATTY LIVER-DISEASE ; NULL MICE ; ENERGY-METABOLISM ; GAMMA ACTIVATION ; TRIBBLES HOMOLOG ; CARDIAC-FUNCTION ; COUP-TFII ; RESISTANCE |
| WOS研究方向 | Endocrinology & Metabolism |
| WOS类目 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000380750400011 |
| 出版者 | AMER DIABETES ASSOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374409 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Guo, Feifan |
| 作者单位 | Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Yajie,Yu, Junjie,Deng, Jiali,et al. A novel function of hepatic fog2 in insulin sensitivity and lipid metabolism through ppar alpha[J]. Diabetes,2016,65(8):2151-2163. |
| APA | Guo, Yajie.,Yu, Junjie.,Deng, Jiali.,Liu, Bin.,Xiao, Yuzhong.,...&Guo, Feifan.(2016).A novel function of hepatic fog2 in insulin sensitivity and lipid metabolism through ppar alpha.Diabetes,65(8),2151-2163. |
| MLA | Guo, Yajie,et al."A novel function of hepatic fog2 in insulin sensitivity and lipid metabolism through ppar alpha".Diabetes 65.8(2016):2151-2163. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。