Fscn1 is required for the trafficking of tgf-beta family type i receptors during endoderm formation
文献类型：期刊论文
| 作者 | Liu, Zhaoting1; Ning, Guozhu1; Xu, Ranran1; Cao, Yu1; Meng, Anming2; Wang, Qiang1,3 |
| 刊名 | Nature communications
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 7页码:15 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms12603 |
| 通讯作者 | Meng, anming(mengam@mail.tsinghua.edu.cn) ; Wang, qiang(qiangwang@ioz.ac.cn) |
| 英文摘要 | Microtubules function in tgf-beta signalling by facilitating the cytoplasmic trafficking of internalized receptors and the nucleocytoplasmic shuttling of smads. however, nothing is known about whether actin filaments are required for these processes. here we report that zebrafish actin-bundling protein fscn1a is highly expressed in mesendodermal precursors and its expression is directly regulated by the tgf-beta superfamily member nodal. knockdown or knockout of fscn1a leads to a reduction of nodal signal transduction and endoderm formation in zebrafish embryos. fscn1 specifically interacts with tgf-beta family type i receptors, and its depletion disrupts the association between receptors and actin filaments and sequesters the internalized receptors into clathrin-coated vesicles. therefore, fscn1 acts as a molecular linker between tgf-beta family type i receptors and the actin filaments to promote the trafficking of internalized receptors from clathrin-coated vesicles to early endosomes during zebrafish endoderm formation. |
| WOS关键词 | CLATHRIN-MEDIATED ENDOCYTOSIS ; INHIBITS MESODERM INDUCTION ; ACTIN BUNDLE FORMATION ; INTERNALIZATION STEP ; CELL MIGRATION ; COATED PITS ; ZEBRAFISH ; FASCIN ; CYTOSKELETON ; EXPRESSION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000381905600001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374420 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Meng, Anming; Wang, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, CAS Ctr Excellence Mol Cell Sci, State Key Lab Membrane Biol, Beijing 100101, Peoples R China 2.Tsinghua Univ, Sch Life Sci, Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China 3.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhaoting,Ning, Guozhu,Xu, Ranran,et al. Fscn1 is required for the trafficking of tgf-beta family type i receptors during endoderm formation[J]. Nature communications,2016,7:15. |
| APA | Liu, Zhaoting,Ning, Guozhu,Xu, Ranran,Cao, Yu,Meng, Anming,&Wang, Qiang.(2016).Fscn1 is required for the trafficking of tgf-beta family type i receptors during endoderm formation.Nature communications,7,15. |
| MLA | Liu, Zhaoting,et al."Fscn1 is required for the trafficking of tgf-beta family type i receptors during endoderm formation".Nature communications 7(2016):15. |
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来源：中国科学院大学
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