Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration
文献类型：期刊论文
| 作者 | Shi, Yaoyao1,2; Wu, Weiwei1,2; Chai, Qian1; Li, Qingqing3; Hou, Yu3; Xia, Huan1,2; Ren, Boyang1,2; Xu, Hairong1; Guo, Xiaohuan4; Jin, Caiwei1,2 |
| 刊名 | Nature communications
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 7页码:12 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms12369 |
| 通讯作者 | Zhu, mingzhao(zhumz@ibp.ac.cn) |
| 英文摘要 | Continuous thymic homing of haematopoietic progenitor cells (hpcs) via the blood is critical for normal t-cell development. however, the nature and the differentiation programme of specialized thymic endothelial cells (ecs) controlling this process remain poorly understood. here using conditional gene-deficient mice, we find that lymphotoxin beta receptor (ltbr) directly controls thymic ecs to guide hpc homing. interestingly, t-cell deficiency or conditional ablation of t-cell-engaged ltbr signalling results in a defect in thymic hpc homing, suggesting the feedback regulation of thymic progenitor homing by thymic products. furthermore, we identify and characterize a special thymic portal ec population with features that guide hpc homing. ltbr is essential for the differentiation and homeostasis of these thymic portal ecs. finally, we show that ltbr is required for t-cell regeneration on irradiation-induced thymic injury. together, these results uncover a cellular and molecular pathway that governs thymic ec differentiation for hpc homing. |
| WOS关键词 | EPITHELIAL-CELLS ; DENDRITIC CELLS ; LYMPH-NODE ; LYMPHOTOXIN PATHWAY ; CENTRAL TOLERANCE ; ADULT THYMUS ; RECEPTOR ; TRANSPLANTATION ; MIGRATION ; RECONSTITUTION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000380860200001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374472 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhu, Mingzhao |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Peking Univ, Coll Life Sci, Biodynam Opt Imaging Ctr, Beijing 100871, Peoples R China 4.Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China 5.UT Southwestern Med Ctr, Dept Pathol & Immunol, Dallas, TX 75235 USA |
| 推荐引用方式 GB/T 7714 | Shi, Yaoyao,Wu, Weiwei,Chai, Qian,et al. Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration[J]. Nature communications,2016,7:12. |
| APA | Shi, Yaoyao.,Wu, Weiwei.,Chai, Qian.,Li, Qingqing.,Hou, Yu.,...&Zhu, Mingzhao.(2016).Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration.Nature communications,7,12. |
| MLA | Shi, Yaoyao,et al."Lt beta r controls thymic portal endothelial cells for haematopoietic progenitor cell homing and t-cell regeneration".Nature communications 7(2016):12. |
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来源：中国科学院大学
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