Dynamically-enhanced retention of gold nanoclusters in hela cells following x-rays exposure: a cell cycle phase-dependent targeting approach
文献类型：期刊论文
| 作者 | Liu, Yan1,2,3,4; Chen, Weiqiang1,2,3; Zhang, Pengcheng1,2,3,4; Jin, Xiaodong1,2,3; Liu, Xinguo1,2,3; Li, Ping1,2,3; Li, Feifei1,2,3,4; Zhang, Hongpeng1; Zou, Guozhang5,6; Li, Qiang1,2,3 |
| 刊名 | Radiotherapy and oncology
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 119期号:3页码:544-551 |
| 关键词 | Ionizing radiation Nano-agents Cell cycle Cellular uptake Synergistic chemo-radiotherapy |
| ISSN号 | 0167-8140 |
| DOI | 10.1016/j.radonc.2016.04.033 |
| 通讯作者 | Li, qiang(liqiang@impcas.ac.cn) |
| 英文摘要 | Background and purpose: cell cycle phase could affect the cellular uptake of nanoparticles. based on the fact that ionizing radiation exposure can delay cell cycle progression including inducing g2/m phase arrest, we propose that ionizing radiation exposure is a cell cycle phase-dependent targeting approach for intracellular delivery of nano-agents in tumor cells. materials and methods: we synthesized luminescent gold nanoclusters (auncs) using a one-pot green synthetic method. subsequently, we used the as-prepared auncs as both "nano-agents" and fluorescent trafficking probes for our study using human cervical carcinoma hela cells. estimating the cellular uptake of auncs and cell cycle analysis were performed following x-rays irradiation and cell synchronization. results: our work showed that x-rays irradiation could delay the division of hela cells and thereby enhance the retention of auncs in hela cells, which is a reverse strategy compared with other studies on synergistic nano-radiotherapy. our results demonstrated that the cell cycle synchronization influenced the cellular uptake processes of auncs, suggesting that dynamic cell cycle progression could affect the cellular uptake kinetics of auncs. conclusion: we consider that the radiation-induced cell division delay might provide a possible mechanism underlying the enhanced effect for the cellular uptake of auncs in irradiated hela cells. (c) 2016 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | NANOPARTICLE UPTAKE ; CANCER-CELLS ; TUMOR-LOCALIZATION ; IONIZING-RADIATION ; PROTEIN-KINASE ; IN-VIVO ; ARREST ; THERAPY ; GROWTH ; SIZE |
| WOS研究方向 | Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS类目 | Oncology ; Radiology, Nuclear Medicine & Medical Imaging |
| 语种 | 英语 |
| WOS记录号 | WOS:000380075400027 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374479 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Beijing 100864, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Beijing 100864, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Natl Ctr Nanosci & Technol China, Beijing, Peoples R China 6.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yan,Chen, Weiqiang,Zhang, Pengcheng,et al. Dynamically-enhanced retention of gold nanoclusters in hela cells following x-rays exposure: a cell cycle phase-dependent targeting approach[J]. Radiotherapy and oncology,2016,119(3):544-551. |
| APA | Liu, Yan.,Chen, Weiqiang.,Zhang, Pengcheng.,Jin, Xiaodong.,Liu, Xinguo.,...&Li, Qiang.(2016).Dynamically-enhanced retention of gold nanoclusters in hela cells following x-rays exposure: a cell cycle phase-dependent targeting approach.Radiotherapy and oncology,119(3),544-551. |
| MLA | Liu, Yan,et al."Dynamically-enhanced retention of gold nanoclusters in hela cells following x-rays exposure: a cell cycle phase-dependent targeting approach".Radiotherapy and oncology 119.3(2016):544-551. |
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来源：中国科学院大学
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