Gains and losses of cis-regulatory elements led to divergence of the arabidopsis apetala1 and cauliflower duplicate genes in the time, space, and level of expression and regulation of one paralog by the other
文献类型：期刊论文
| 作者 | Ye, Lingling1,2; Wang, Bin1,2; Zhang, Wengen1,2; Shan, Hongyan1; Kong, Hongzhi1 |
| 刊名 | Plant physiology
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 171期号:2页码:1055-1069 |
| ISSN号 | 0032-0889 |
| DOI | 10.1104/pp.16.00320 |
| 通讯作者 | Shan, hongyan(shanhongyan@ibcas.ac.cn) ; Kong, hongzhi(hzkong@ibcas.ac.cn) |
| 英文摘要 | How genes change their expression patterns over time is still poorly understood. here, by conducting expression, functional, bioinformatic, and evolutionary analyses, we demonstrate that the differences between the arabidopsis (arabidopsis thaliana) apetala1 (ap1) and cauliflower (cal) duplicate genes in the time, space, and level of expression were determined by the presence or absence of functionally important transcription factor-binding sites (tfbss) in regulatory regions. in particular, a carg box, which is the autoregulatory site of ap1 that can also be bound by the cal protein, is a key determinant of the expression differences. because of the carg box, ap1 is both autoregulated and cross-regulated (by ap1 and cal, respectively), and its relatively high-level expression is maintained till to the late stages of sepal and petal development. the observation that the carg box was gained recently further suggests that the autoregulation and cross-regulation of ap1, as well as its function in sepal and petal development, are derived features. by comparing the evolutionary histories of this and other tfbss, we further indicate that the divergence of ap1 and cal in regulatory regions has been markedly asymmetric and can be divided into several stages. specifically, shortly after duplication, when ap1 happened to be the paralog that maintained the function of the ancestral gene, cal experienced certain degrees of degenerate evolution, in which several functionally important tfbss were lost. later, when functional divergence allowed the survival of both paralogs, cal remained largely unchanged in expression, whereas the functions of ap1 were gradually reinforced by gains of the carg box and other tfbss. |
| WOS关键词 | MADS-BOX GENE ; HOMEOTIC PROTEINS APETALA1 ; DNA-BINDING PROPERTIES ; FLORAL ORGAN IDENTITY ; FLOWER DEVELOPMENT ; MERISTEM IDENTITY ; TRANSCRIPTION FACTORS ; MOLECULAR-BASIS ; EVOLUTION ; THALIANA |
| WOS研究方向 | Plant Sciences |
| WOS类目 | Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000380699200024 |
| 出版者 | AMER SOC PLANT BIOLOGISTS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374488 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shan, Hongyan; Kong, Hongzhi |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Systemat & Evolutionary Bot, Beijing 100093, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Lingling,Wang, Bin,Zhang, Wengen,et al. Gains and losses of cis-regulatory elements led to divergence of the arabidopsis apetala1 and cauliflower duplicate genes in the time, space, and level of expression and regulation of one paralog by the other[J]. Plant physiology,2016,171(2):1055-1069. |
| APA | Ye, Lingling,Wang, Bin,Zhang, Wengen,Shan, Hongyan,&Kong, Hongzhi.(2016).Gains and losses of cis-regulatory elements led to divergence of the arabidopsis apetala1 and cauliflower duplicate genes in the time, space, and level of expression and regulation of one paralog by the other.Plant physiology,171(2),1055-1069. |
| MLA | Ye, Lingling,et al."Gains and losses of cis-regulatory elements led to divergence of the arabidopsis apetala1 and cauliflower duplicate genes in the time, space, and level of expression and regulation of one paralog by the other".Plant physiology 171.2(2016):1055-1069. |
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来源：中国科学院大学
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