The atpase hcinap regulates 18s rrna processing and is essential for embryogenesis and tumour growth
文献类型：期刊论文
| 作者 | Bai, Dongmei1,2; Zhang, Jinfang1,2; Li, Tingting1,2; Hang, Runlai3,4,5; Liu, Yong1,2; Tian, Yonglu2; Huang, Dadu2; Qu, Linglong1,2; Cao, Xiaofeng3,4,5; Ji, Jiafu6 |
| 刊名 | Nature communications
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 7页码:15 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms12310 |
| 通讯作者 | Zheng, xiaofeng(xiaofengz@pku.edu.cn) |
| 英文摘要 | Dysfunctions in ribosome biogenesis cause developmental defects and increased cancer susceptibility; however, the connection between ribosome assembly and tumorigenesis remains unestablished. here we show that hcinap (also named ak6) is required for human 18s rrna processing and 40s subunit assembly. homozygous cinap(-/-) mice show embryonic lethality. the heterozygotes are viable and show defects in 18s rrna processing, whereas no delayed cell growth is observed. however, during rapid growth, cinap haploinsufficiency impairs protein synthesis. consistently, hcinap depletion in fast-growing cancer cells inhibits ribosome assembly and abolishes tumorigenesis. these data demonstrate that hcinap reduction is a specific rate-limiting controller during rapid growth. notably, hcinap is highly expressed in cancers and correlated with a worse prognosis. genome-wide polysome profiling shows that hcinap selectively modulates cancer-associated translatome to promote malignancy. our results connect the role of hcinap in ribosome assembly with tumorigenesis. modulation of hcinap expression may be a promising target for cancer therapy. |
| WOS关键词 | DIAMOND-BLACKFAN ANEMIA ; TRANSLATIONAL CONTROL ; ADENYLATE KINASE ; PROTEIN S14 ; PIN DOMAIN ; C-MYC ; BIOGENESIS ; CANCER ; TRANSCRIPTION ; PROGRESSION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000380851700001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374501 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zheng, Xiaofeng |
| 作者单位 | 1.Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China 2.Peking Univ, Sch Life Sci, Dept Biochem & Mol Biol, Yiheyuan Rd 5, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, State key Lab Plant Genet, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Genet & Dev Biol, Natl Ctr Plant Gene Res, Beijing 100101, Peoples R China 5.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100039, Peoples R China 6.Peking Univ, Caner Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Dongmei,Zhang, Jinfang,Li, Tingting,et al. The atpase hcinap regulates 18s rrna processing and is essential for embryogenesis and tumour growth[J]. Nature communications,2016,7:15. |
| APA | Bai, Dongmei.,Zhang, Jinfang.,Li, Tingting.,Hang, Runlai.,Liu, Yong.,...&Zheng, Xiaofeng.(2016).The atpase hcinap regulates 18s rrna processing and is essential for embryogenesis and tumour growth.Nature communications,7,15. |
| MLA | Bai, Dongmei,et al."The atpase hcinap regulates 18s rrna processing and is essential for embryogenesis and tumour growth".Nature communications 7(2016):15. |
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来源：中国科学院大学
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