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Prioritizing functional phosphorylation sites based on multiple feature integration

文献类型：期刊论文

作者Xiao, Qingyu1,2; Miao, Benpeng1,2; Bi, Jie2,3; Wang, Zhen1; Li, Yixue1,4
刊名Scientific reports
出版日期2016-04-19
卷号6页码:9
ISSN号2045-2322
DOI10.1038/srep24735
通讯作者Wang, zhen(zwang01@sibs.ac.cn) ; Li, yixue(yxli@sibs.ac.cn)
英文摘要Protein phosphorylation is an important type of post-translational modification that is involved in a variety of biological activities. most phosphorylation events occur on serine, threonine and tyrosine residues in eukaryotes. in recent years, many phosphorylation sites have been identified as a result of advances in mass-spectrometric techniques. however, a large percentage of phosphorylation sites may be non-functional. systematically prioritizing functional sites from a large number of phosphorylation sites will be increasingly important for the study of their biological roles. this study focused on exploring the intrinsic features of functional phosphorylation sites to predict whether a phosphosite is likely to be functional. we found significant differences in the distribution of evolutionary conservation, kinase association, disorder score, and secondary structure between known functional and background phosphorylation datasets. we built four different types of classifiers based on the most representative features and found that their performances were similar. we also prioritized 213,837 human phosphorylation sites from a variety of phosphorylation databases, which will be helpful for subsequent functional studies. all predicted results are available for query and download on our website (predict functional phosphosites, pfp, http://pfp.biosino.org/).
WOS关键词INCORPORATING EVOLUTIONARY INFORMATION ; INTRINSICALLY UNSTRUCTURED PROTEINS ; MASS-SPECTROMETRY ; POSTTRANSLATIONAL MODIFICATIONS ; SIGNALING NETWORKS ; PREDICTION ; DISORDER ; CONSERVATION ; GENERATION ; DYNAMICS
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
语种英语
WOS记录号WOS:000381312700001
出版者NATURE PUBLISHING GROUP
URI标识http://www.irgrid.ac.cn/handle/1471x/2374505
专题中国科学院大学
通讯作者Wang, Zhen; Li, Yixue
作者单位1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China
4.Shanghai Ind Technol Inst, Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Xiao, Qingyu,Miao, Benpeng,Bi, Jie,et al. Prioritizing functional phosphorylation sites based on multiple feature integration[J]. Scientific reports,2016,6:9.
APA Xiao, Qingyu,Miao, Benpeng,Bi, Jie,Wang, Zhen,&Li, Yixue.(2016).Prioritizing functional phosphorylation sites based on multiple feature integration.Scientific reports,6,9.
MLA Xiao, Qingyu,et al."Prioritizing functional phosphorylation sites based on multiple feature integration".Scientific reports 6(2016):9.

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来源：中国科学院大学

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