Common aging signature in the peripheral blood of vascular dementia and alzheimer's disease
文献类型：期刊论文
| 作者 | Luo, Hongbo1; Han, Guangchun2; Wang, Jiajia2,3; Zeng, Fan4,5; Li, Yuanming1; Shao, Shaoju1; Song, Fuhai2,3; Bai, Zhouxian2,3; Peng, Xing2,3; Wang, Yan-Jiang4,5 |
| 刊名 | Molecular neurobiology
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 53期号:6页码:3596-3605 |
| 关键词 | Vascular dementia Alzheimer's disease Peripheral blood Gene expression Ribosome |
| ISSN号 | 0893-7648 |
| DOI | 10.1007/s12035-015-9288-x |
| 通讯作者 | Shi, xiangqun(shixq_2003@163.com) ; Lei, hongxing(leihx@big.ac.cn) |
| 英文摘要 | Alzheimer's disease (ad) and vascular dementia (vad) are the two most dominant forms of dementia in elderly people. due to the large overlap between ad and vad in clinical observations, great controversies exist regarding the distinction and connection between these two types of senile dementia. here for the first time, we resort to the gene expression pattern of the peripheral blood to compare ad and vad objectively. in our previous work, we have demonstrated that the dysregulation of gene expression in ad is unique among the examined diseases including neurological diseases, cancer, and metabolic diseases. in this study, we found that the dysregulation of gene expression in ad and vad is quite similar to each other at both functional and gene levels. interestingly, the dysregulation started at the early stages of the diseases, namely mild cognitive impairment (mci) and vascular cognitive impairment (vci). we have also shown that this signature is distinctive from that of peripheral vascular diseases. comparison with aging studies revealed that the most profound change in ad and vad, namely ribosome, is consistent with the accelerated aging scenario. this study may have implications to the common mechanism between ad and vad. |
| WOS关键词 | CORONARY-ARTERY-DISEASE ; MILD COGNITIVE IMPAIRMENT ; GENE-EXPRESSION PATTERNS ; WHOLE-BLOOD ; RATING-SCALE ; RISK-FACTORS ; S100A12 ; MARKER ; METAANALYSIS ; METABOLISM |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000379707600008 |
| 出版者 | HUMANA PRESS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374510 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shi, Xiangqun; Lei, Hongxing |
| 作者单位 | 1.Lanzhou Mil Area Command, Lanzhou Gen Hosp, Dept Neurol, Lanzhou 730050, Gansu, Peoples R China 2.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing 100053, Peoples R China 5.Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing 100053, Peoples R China 6.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100053, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Hongbo,Han, Guangchun,Wang, Jiajia,et al. Common aging signature in the peripheral blood of vascular dementia and alzheimer's disease[J]. Molecular neurobiology,2016,53(6):3596-3605. |
| APA | Luo, Hongbo.,Han, Guangchun.,Wang, Jiajia.,Zeng, Fan.,Li, Yuanming.,...&Lei, Hongxing.(2016).Common aging signature in the peripheral blood of vascular dementia and alzheimer's disease.Molecular neurobiology,53(6),3596-3605. |
| MLA | Luo, Hongbo,et al."Common aging signature in the peripheral blood of vascular dementia and alzheimer's disease".Molecular neurobiology 53.6(2016):3596-3605. |
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来源：中国科学院大学
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