The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma hepg2 cells under x-ray irradiation
文献类型：期刊论文
| 作者 | Liu, Xi1,2,3,4; Liu, Yan1,2,3,4; Zhang, Pengcheng1,2,3,4; Jin, Xiaodong1,2,3; Zheng, Xiaogang1,2,3,4; Ye, Fei1,2,3,4; Chen, Weiqiang1,2,3; Li, Qiang1,2,3 |
| 刊名 | International journal of nanomedicine
 |
| 出版日期 | 2016 |
| 卷号 | 11页码:3517-3530 |
| 关键词 | Aunps Radiation enhancement Synergistic effect Human hepatoma cells Hydroxyl radical production |
| ISSN号 | 1178-2013 |
| DOI | 10.2147/ijn.s105348 |
| 通讯作者 | Chen, weiqiang(chenwq7315@impcas.ac.cn) ; Li, qiang(liqiang@impcas.ac.cn) |
| 英文摘要 | Reductive drug-functionalized gold nanoparticles (aunps) have been proposed to enhance the damage of x-rays to cells through improving hydroxyl radical production by secondary electrons. in this work, polyethylene glycol-capped aunps were conjugated with tirapazamine (tpz) moiety, and then thioctyl tpz (tpzs)-modified aunps (tpzs-aunps) were synthesized. the tpzs-aunps were characterized by transmission electron microscopy, ultraviolet-visible spectra, dynamic light scattering, and inductively coupled plasma mass spectrometry to have a size of 16.6 +/- 2.1 nm in diameter and a tpzs/aunps ratio of similar to 700:1. in contrast with pegylated aunps, the as-synthesized tpzs-aunps exhibited 20% increment in hydroxyl radical production in water at 2.0 gy, and 19% increase in sensitizer enhancement ratio at 10% survival fraction for human hepatoma hepg2 cells under x-ray irradiation. the production of reactive oxygen species in hepg2 cells exposed to x-rays in vitro demonstrated a synergistic radiosensitizing effect of aunps and tpz moiety. thus, the reductive drug-conjugated tpzs-aunps as a kind of aunp radiosensitizer with low gold loading provide a new strategy for enhancing the efficacy of radiation therapy. |
| WOS关键词 | RADIATION-THERAPY ; PARTICLE-SIZE ; ENHANCEMENT ; AGENTS ; DNA ; RADIOTHERAPY ; 1,4-DIOXIDE ; CLEAVAGE ; ASSAY ; MICE |
| WOS研究方向 | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| WOS类目 | Nanoscience & Nanotechnology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000380387400001 |
| 出版者 | DOVE MEDICAL PRESS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374520 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Weiqiang; Li, Qiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou, Gansu, Peoples R China 2.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou, Gansu, Peoples R China 3.Key Lab Basic Res Heavy Ion Radiat Applicat Med, Lanzhou, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Sch Life Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xi,Liu, Yan,Zhang, Pengcheng,et al. The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma hepg2 cells under x-ray irradiation[J]. International journal of nanomedicine,2016,11:3517-3530. |
| APA | Liu, Xi.,Liu, Yan.,Zhang, Pengcheng.,Jin, Xiaodong.,Zheng, Xiaogang.,...&Li, Qiang.(2016).The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma hepg2 cells under x-ray irradiation.International journal of nanomedicine,11,3517-3530. |
| MLA | Liu, Xi,et al."The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma hepg2 cells under x-ray irradiation".International journal of nanomedicine 11(2016):3517-3530. |
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来源：中国科学院大学
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