Systemic localization of seven major types of carbohydrates on cell membranes by dstorm imaging
文献类型：期刊论文
| 作者 | Chen, Junling1,2; Gao, Jing1,2; Zhang, Min1,2; Cai, Mingjun1; Xu, Haijiao1; Jiang, Junguang1; Tian, Zhiyuan3; Wang, Hongda1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2016-07-25 |
| 卷号 | 6页码:10 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep30247 |
| 通讯作者 | Wang, hongda(hdwang@ciac.ac.cn) |
| 英文摘要 | Carbohydrates on the cell surface control intercellular interactions and play a vital role in various physiological processes. however, their systemic distribution patterns are poorly understood. through the direct stochastic optical reconstruction microscopy (dstorm) strategy, we systematically revealed that several types of representative carbohydrates are found in clustered states. interestingly, the results from dual-color dstorm imaging indicate that these carbohydrate clusters are prone to connect with one another and eventually form conjoined platforms where different functional glycoproteins aggregate (e.g., epidermal growth factor receptor, (egfr) and band 3 protein). a thorough understanding of the ensemble distribution of carbohydrates on the cell surface paves the way for elucidating the structure-function relationship of cell membranes and the critical roles of carbohydrates in various physiological and pathological cell processes. |
| WOS关键词 | PLASMA-MEMBRANE ; SURFACE GLYCANS ; BINDING-SPECIFICITY ; MAACKIA-AMURENSIS ; LIGAND-BINDING ; LECTIN-BINDING ; CANCER-CELLS ; PROTEIN ; GLYCOSYLATION ; ORGANIZATION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000380187900001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374527 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Hongda |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Junling,Gao, Jing,Zhang, Min,et al. Systemic localization of seven major types of carbohydrates on cell membranes by dstorm imaging[J]. Scientific reports,2016,6:10. |
| APA | Chen, Junling.,Gao, Jing.,Zhang, Min.,Cai, Mingjun.,Xu, Haijiao.,...&Wang, Hongda.(2016).Systemic localization of seven major types of carbohydrates on cell membranes by dstorm imaging.Scientific reports,6,10. |
| MLA | Chen, Junling,et al."Systemic localization of seven major types of carbohydrates on cell membranes by dstorm imaging".Scientific reports 6(2016):10. |
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来源：中国科学院大学
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