Multifunctional ucnps@pda-icg nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy
文献类型：期刊论文
| 作者 | Liu, Bei1,4; Li, Chunxia1; Xing, Bengang2; Yang, Piaoping3; Lin, Jun1 |
| 刊名 | Journal of materials chemistry b
 |
| 出版日期 | 2016 |
| 卷号 | 4期号:28页码:4884-4894 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/c6tb00799f |
| 通讯作者 | Li, chunxia(cxli@ciac.ac.cn) ; Lin, jun(jlin@ciac.ac.cn) |
| 英文摘要 | Integrated theranostic nanosystems that combine therapeutic methods with suitable medical imaging modality are highly needed in the improvement of cancer theranostic approaches. herein, polydopamine (pda)-shelled nayf4:yb,er@nayf4:yb nanoparticles (ucnps) capable of loading indocyanine green (icg) molecules via electrostatic adsorption, hydrophobic interaction and p-p stacking were successfully designed and synthesized (ucnps@pda-icg, denoted as upi) for upconversion imaging and combined photothermal/photodynamic therapy (ptt/pdt) with enhanced antitumor efficacy. we have found that icg in this novel anticancer nanoplatform can be triggered impressively by 808-nm irradiation to produce both a photothermal effect and cytotoxic reactive oxygen species (ros), thus achieving a good ptt/pdt synergistic effect. notably, compared with free icg molecules, upi nanocomposites show much higher photostability and thermal stability. both in vitro and in vivo experiments show that the as-obtained upi can ablate cancer cells effectively with 808-nm irradiation, revealing their great potential as a nir-mediated dual-modal therapeutic platform. meanwhile, the core of ucnps can be used for ucl imaging. all these results demonstrate great potentiality of upi as a novel type of theranostic agent for the treatment of tumors. |
| WOS关键词 | GUIDED PHOTOTHERMAL THERAPY ; IN-VIVO ; SYNERGISTIC THERAPY ; THERANOSTIC NANOPARTICLES ; SHELL NANOPARTICLES ; INDOCYANINE GREEN ; CANCER-CELLS ; TUMOR ; NANOCRYSTALS ; NANOPLATFORM |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000379570000011 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374541 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Chunxia; Lin, Jun |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China 2.Nanyang Technol Univ, Sch Phys & Math Sci, Singapore, Singapore 3.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Minist Educ, Key Lab Superlight Mat & Surface Technol, Harbin 150001, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Bei,Li, Chunxia,Xing, Bengang,et al. Multifunctional ucnps@pda-icg nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy[J]. Journal of materials chemistry b,2016,4(28):4884-4894. |
| APA | Liu, Bei,Li, Chunxia,Xing, Bengang,Yang, Piaoping,&Lin, Jun.(2016).Multifunctional ucnps@pda-icg nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy.Journal of materials chemistry b,4(28),4884-4894. |
| MLA | Liu, Bei,et al."Multifunctional ucnps@pda-icg nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy".Journal of materials chemistry b 4.28(2016):4884-4894. |
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来源：中国科学院大学
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