Meta-selective c-ar-h nitration of arenes through a ru-3(co)(12)-catalyzed ortho-metalation strategy
文献类型：期刊论文
| 作者 | Fan, Zhoulong1,2,3; Ni, Jiabin1,2,3; Zhang, Ao1,2,3 |
| 刊名 | Journal of the american chemical society
 |
| 出版日期 | 2016-07-13 |
| 卷号 | 138期号:27页码:8470-8475 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/jacs.6b03402 |
| 通讯作者 | Zhang, ao(aozhang@simm.ac.cn) |
| 英文摘要 | The first example of transition metal-catalyzed meta-selective c-ar-h nitration of arenes is described. with the use of ru-3(co)(12) as the catalyst and cu(no3)(2)center dot 3h(2)o as the nitro source, a wide spectrum of arenes bearing diversified n-heterocycles or oximido as the directing groups were nitrated with meta selectivity exclusively. mechanism studies have demonstrated the formation of a new 18e-octahedral ruthenium species as a key ortho-c-ar-h metalated intermediate, which may be responsible for the subsequent meta-selective electrophilic aromatic substitution (sear). moreover, this approach provides a fast-track strategy for atom/step economical synthesis of many useful pharmaceutical molecules. |
| WOS关键词 | U-SHAPED TEMPLATE ; TRACELESS DIRECTING GROUPS ; BOND FUNCTIONALIZATION ; CARBOXYLIC-ACIDS ; NATURAL-PRODUCTS ; DIRECT ARYLATION ; PD CATALYSTS ; ACTIVATION ; OLEFINATION ; NITROARENES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000379794400030 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374583 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med SIMM, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Synthet Organ & Med Chem Lab SOMCL, Shanghai Inst Mat Med SIMM, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Zhoulong,Ni, Jiabin,Zhang, Ao. Meta-selective c-ar-h nitration of arenes through a ru-3(co)(12)-catalyzed ortho-metalation strategy[J]. Journal of the american chemical society,2016,138(27):8470-8475. |
| APA | Fan, Zhoulong,Ni, Jiabin,&Zhang, Ao.(2016).Meta-selective c-ar-h nitration of arenes through a ru-3(co)(12)-catalyzed ortho-metalation strategy.Journal of the american chemical society,138(27),8470-8475. |
| MLA | Fan, Zhoulong,et al."Meta-selective c-ar-h nitration of arenes through a ru-3(co)(12)-catalyzed ortho-metalation strategy".Journal of the american chemical society 138.27(2016):8470-8475. |
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来源：中国科学院大学
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