N-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines
文献类型：期刊论文
| 作者 | Li, Qiurong1; Zhang, Qiang1; Wang, Meng1,3; Zhao, Sumin2; Xu, Guowang2; Li, Jieshou1 |
| 刊名 | molecular immunology
 |
| 出版日期 | 2008-03-01 |
| 卷号 | 45期号:5页码:1356-1365 |
| 关键词 | n-3 PUFAs lipid composition phospholipids tight junction tight junction proteins |
| 产权排序 | 2;4 |
| 通讯作者 | 黎介寿 |
| 英文摘要 | defects in tight junction barrier have been considered as an important etiologic factor of crohn's disease. n-3 polyunsaturated fatty acids (pufas) exert beneficial effects on inflammatory bowel disorders. however, the mechanisms remain unknown. we found that docosahexaenoic acid (dha, 22:6 n-3) and eicosapentaenoic acid (epa, 20:5 n-3) changed lipid environment in membrane microdomains of tight junction in vitro. n-3 pufas treatment effectively prevented the redistribution of occludin and zo-1 and distortion of tj morphology, reduced transepithelial electrical resistance induced by ifn-gamma and tnf-alpha. we also observed dramatic reorganization of tj proteins in epithelial lateral membrane following treatment with these cytokines. our findings for first time indicate that n-3 pufas play an important role in proinflammatory cytokines-induced permeability defects and epithelial barrier dysfunction by modifying lipid environment in membrane microdomains of tight junction. (c) 2007 elsevier ltd. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemistry & molecular biology ; immunology |
| 研究领域[WOS] | biochemistry & molecular biology ; immunology |
| 关键词[WOS] | tight junction permeability ; inflammatory-bowel-disease ; tumor-necrosis-factor ; crohns-disease ; intestinal permeability ; lipid-composition ; interferon-gamma ; membrane rafts ; proteins ; mechanisms |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000253030000017 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/100425]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China 2.Chinese Acad Sci, Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China 3.Nanjing Univ, Sch Med, Nanjing 210093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qiurong,Zhang, Qiang,Wang, Meng,et al. N-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines[J]. molecular immunology,2008,45(5):1356-1365. |
| APA | Li, Qiurong,Zhang, Qiang,Wang, Meng,Zhao, Sumin,Xu, Guowang,&Li, Jieshou.(2008).N-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines.molecular immunology,45(5),1356-1365. |
| MLA | Li, Qiurong,et al."N-3 polyunsaturated fatty acids prevent disruption of epithelial barrier function induced by proinflammatory cytokines".molecular immunology 45.5(2008):1356-1365. |
入库方式： OAI收割
来源：大连化学物理研究所
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