Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional chinese medicines
文献类型：期刊论文
| 作者 | Xu, Tengfei1,2; Liu, Shu1; Meng, Lulu3; Pi, Zifeng1; Song, Fengrui1; Liu, Zhiqiang1 |
| 刊名 | Journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2016-07-15 |
| 卷号 | 1026页码:56-66 |
| 关键词 | Diterpendoid alkaloids Analysis methods Biological activity Metabolism Biotransformation |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2015.09.023 |
| 通讯作者 | Pi, zifeng(mslab21@ciac.ac.cn) ; Liu, zhiqiang(liuzq@ciac.ac.cn) |
| 英文摘要 | The diterpenoid alkaloids as one type of heterocyclic alkaloids have been found in many traditional herbal medicines, such as genus consolida, aconitum, and delphinium (ranunculaceae). pharmacological researches have indicated that many diterpenoid alkaloids are the main bioactive components which have analgesic, anti-inflammatory, anti-microbial, anti-tumor, cardiotonic, and anti-arrhythmic activities. studies focused on the determination, quantitation and pharmacological properties of these alkaloids have dramatically increased during the past few years. up to now, newly discovered diterpenoid alkaloids with important biological activities have been isolated and synthesized. considering their significant role and diffusely used in many disease treatments, we summarized the information of their analysis methods, bioactivity, metabolism and biotransformation in vivo as well as the pharmacological mechanisms. based on above review, the further researches are suggested. (c) 2015 elsevier b.v. all rights reserved. |
| WOS关键词 | TANDEM-MASS-SPECTROMETRY ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; COUNTER-CURRENT CHROMATOGRAPHY ; HUMAN INTESTINAL BACTERIA ; RADIX-ACONITI-PREPARATA ; HIGHLY TOXIC ACONITINE ; GANCAO HERB-PAIR ; LC-ESI-MS/MS ; IN-VITRO ; NORDITERPENOID ALKALOIDS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000379636800007 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374642 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Pi, Zifeng; Liu, Zhiqiang |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Electroanalyt Chem, Natl Ctr Mass Spectrometry Changchun,Changchun In, Jilin Prov Key Lab Chinese Med Chem & Mass Spectr, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Jilin Prov Sci & Technol Dept, Changchun 130041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Tengfei,Liu, Shu,Meng, Lulu,et al. Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional chinese medicines[J]. Journal of chromatography b-analytical technologies in the biomedical and life sciences,2016,1026:56-66. |
| APA | Xu, Tengfei,Liu, Shu,Meng, Lulu,Pi, Zifeng,Song, Fengrui,&Liu, Zhiqiang.(2016).Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional chinese medicines.Journal of chromatography b-analytical technologies in the biomedical and life sciences,1026,56-66. |
| MLA | Xu, Tengfei,et al."Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional chinese medicines".Journal of chromatography b-analytical technologies in the biomedical and life sciences 1026(2016):56-66. |
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来源：中国科学院大学
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