Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Ma, Chenfei1; Wang, Huahong2; Lu, Xin1; Xu, Guowang1; Liu, Benye2 |
| 刊名 | journal of chromatography a
 |
| 出版日期 | 2008-04-04 |
| 卷号 | 1186期号:1-2页码:412-419 |
| 关键词 | Artemisia annua L. metabolic fingerprinting metabolomics pattern recognition developmental stage |
| 产权排序 | 1;1 |
| 通讯作者 | 许国旺 |
| 英文摘要 | artemisia annua l. is an annual herb native of asia and this plant has been famous for the discovery of the anti-malarial drug artemisinin since 1971. in this work, to investigate variety of whole metabolites, metabolic fingerprinting analysis of a. annua l. was carried out by gc and gc-ms coupled with trimethylsilyl derivatisation. principal component analysis and partial least squares discriminant analysis were employed to classify gc data of a. annua l. samples at five developmental stages. the results indicated that there was no distinct difference of metabolites between control (001) and transgenic strain (f4) from the tender seedling stage to adult seedling stage, but clear differences were detected at pre-flower budding stage, flower budding stage and full flowering stage. three precursors of artemisinin biosynthesis were studied at five developmental stages and found that a possible bottleneck exists in the conversion from artemisinic acid or dihydroartemisinic acid to artemisinin. (c) 2007 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | performance liquid-chromatography ; dihydroartemisinic acid ; biosynthetic precursors ; identification ; h-1-nmr ; plants |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000254884700036 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/100431]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatograph R&A Ctr, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Chenfei,Wang, Huahong,Lu, Xin,et al. Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry[J]. journal of chromatography a,2008,1186(1-2):412-419. |
| APA | Ma, Chenfei,Wang, Huahong,Lu, Xin,Xu, Guowang,&Liu, Benye.(2008).Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry.journal of chromatography a,1186(1-2),412-419. |
| MLA | Ma, Chenfei,et al."Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography-mass spectrometry".journal of chromatography a 1186.1-2(2008):412-419. |
入库方式： OAI收割
来源：大连化学物理研究所
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