The transcription factor skn7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus hirsutella minnesotensis
文献类型：期刊论文
| 作者 | Hussain, Muzammil1,2; Hamid, M. Imran1,3; Wang, Niuniu1,2; Bin, Lin1,2; Xiang, Meichun1; Liu, Xingzhong1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2016-07-20 |
| 卷号 | 6页码:12 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep30047 |
| 通讯作者 | Xiang, meichun(xiangmc@im.ac.cn) ; Liu, xingzhong(liuxz@im.ac.cn) |
| 英文摘要 | The transcription factor skn7 is a highly conserved protein among fungi and was initially recognized as a response regulator that protects cells from oxidative stress and maintains cell wall integrity in yeast. orthologs of skn7 are extensively present in biocontrol agents of plant pathogens, but they had not been functionally characterized. here, we identified and characterized the transcription factor skn7 in the nematode endoparasitic fungus hirsutella minnesotensis. null mutant lacking him-skn7 (him_03620), which was generated by a gene disruption strategy, demonstrated reduced conidiation, increased sensitivity to high temperature, hydrogen peroxide, mannitol and ethanol, and reduced fungal resistance to farnesol. however, over-expression mutant showed increased conidial production, thermotolerance and resistance to farnesol, suggesting that him-skn7 regulates antiapoptotic-like cell death in h. minnesotensis. moreover, the results showed that in null mutant, h. minnesotensis had decreased endoparasitic ability as compared to wild type and over-expression strain. during the infection process, the relative expression of the him-skn7 gene was significantly induced in the wild type and over-expression strain. the results of the present study advance our understanding of the functions of the skn7 gene in biocontrol agents, in particular, nematode endoparasitic fungi. |
| WOS关键词 | 2-COMPONENT SIGNAL TRANSDUCERS ; HEAT-SHOCK PROTEINS ; SACCHAROMYCES-CEREVISIAE ; CONIOTHYRIUM-MINITANS ; HETERODERA-GLYCINES ; RESPONSE REGULATOR ; OXIDATIVE STRESS ; GENE-EXPRESSION ; SOYBEAN FIELDS ; BUDDING YEAST |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000379920900001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374673 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xiang, Meichun; Liu, Xingzhong |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, 3 Pk 1,Beichen West Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Univ Sargodha, Univ Coll Agr, Dept Plant Pathol, Sargodha 40100, Pakistan |
| 推荐引用方式 GB/T 7714 | Hussain, Muzammil,Hamid, M. Imran,Wang, Niuniu,et al. The transcription factor skn7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus hirsutella minnesotensis[J]. Scientific reports,2016,6:12. |
| APA | Hussain, Muzammil,Hamid, M. Imran,Wang, Niuniu,Bin, Lin,Xiang, Meichun,&Liu, Xingzhong.(2016).The transcription factor skn7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus hirsutella minnesotensis.Scientific reports,6,12. |
| MLA | Hussain, Muzammil,et al."The transcription factor skn7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus hirsutella minnesotensis".Scientific reports 6(2016):12. |
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来源：中国科学院大学
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