Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry
文献类型：期刊论文
| 作者 | Li, Qiurong1; Zhang, Qiang1; Xu, Guowang2; Yin, Peiyuan2; Li, Ning1; Li, Jieshou1 |
| 刊名 | digestion
 |
| 出版日期 | 2008 |
| 卷号 | 77期号:2页码:122-130 |
| 关键词 | metabonomics intestinal transplantation ultrahigh-performance liquid chromatography time-of-flight mass spectrometry biomarker |
| 产权排序 | 2;3 |
| 通讯作者 | 黎介寿 |
| 英文摘要 | background: intestinal transplantation is a potential treatment for patients with irreversible intestinal failure. however, the long-term outcome is still unsatisfactory compared with transplantation of other solid organs because of transplantation rejection. therefore, early detection and accurate diagnosis of rejection is essential. recently, metabonomics has become a platform for monitoring of the process of organ transplantation. methods: the metabolite profiling in the plasma was measured by ultrahigh-performance liquid chromatography time-of-flight mass spectrometry in a patient with intestinal transplantation and it was analyzed by principal component analysis and simca-p. results: the differences between the patient and controls were achieved in the principal component analysis score plot. the potential biomarkers of rejection, including lysophosphatidyl choline, phenylalanine and tryptophan, were identified in the transplantation patient. conclusion: the analysis here may provide a fundamental and powerful approach to inspect the disease metabolic status and screening tool for marker candidates. copyright (c) 2008 s. karger ag, basel. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | gastroenterology & hepatology |
| 研究领域[WOS] | gastroenterology & hepatology |
| 关键词[WOS] | magnetic-resonance spectroscopy ; human liver-transplantation ; renal-transplantation ; nephrectomized mice ; reperfusion injury ; metabolites ; rejection ; urine ; rats ; ms |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000254893300009 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/100439]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Jinling Hosp, Inst Gen Surg, Nanjing 210002, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qiurong,Zhang, Qiang,Xu, Guowang,et al. Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry[J]. digestion,2008,77(2):122-130. |
| APA | Li, Qiurong,Zhang, Qiang,Xu, Guowang,Yin, Peiyuan,Li, Ning,&Li, Jieshou.(2008).Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry.digestion,77(2),122-130. |
| MLA | Li, Qiurong,et al."Metabonomics study of intestinal transplantation using ultrahigh-performance liquid chromatography time-of-flight mass spectrometry".digestion 77.2(2008):122-130. |
入库方式： OAI收割
来源：大连化学物理研究所
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