Self-assembly of porphyrin-paclitaxel conjugates into nanomedicines: enhanced cytotoxicity due to endosomal escape
文献类型：期刊论文
| 作者 | Zheng, Xiaohua1,2; Li, Zhensheng1; Chen, Li3; Xie, Zhigang1; Jing, Xiabin1 |
| 刊名 | Chemistry-an asian journal
 |
| 出版日期 | 2016-06-21 |
| 卷号 | 11期号:12页码:1780-1784 |
| 关键词 | Conjugates Nanomedicines Paclitaxel Porphyrin Self-assembly |
| ISSN号 | 1861-4728 |
| DOI | 10.1002/asia.201600423 |
| 通讯作者 | Xie, zhigang(xiez@ciac.ac.cn) |
| 英文摘要 | Nanomedicines assembled directly from drug molecules possess several advantages, including precise molecular structure and high content of drugs. herein, porphyrin-paclitaxel conjugates (py-s-s-ptx) were synthesized by using a disulfide bond as a linker. the py-s-s-ptx could self-assemble into nanoparticles (py-s-s-ptx nps) with a size of about 100nm via disulfide-induced assembly. py-s-s-ptx nps are highly stable under biological conditions and could be destroyed in the presence of reducing agents as revealed by dynamic light scattering. the obtained py-s-s-ptx nps could be internalized by cancer cells via endocytosis and disassociated in the reducing cytoplasm, thus releasing ptx in cancer cells. endosomal escape triggered upon irradiation could enhance the cytotoxicity of paclitaxel, and py-s-s-ptx nps possess cytotoxicity comparable to that of free ptx. we believe that this disulfide-assembled nanomedicine represents a new and important development for chemotherapy in cancer therapy. |
| WOS关键词 | PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; IN-VITRO ; DRUG-RELEASE ; SUPRAMOLECULAR NANOSTRUCTURES ; EFFICIENT PHOTOSENSITIZERS ; ZINC(II) PHTHALOCYANINES ; NANOPARTICLES ; DELIVERY ; DISULFIDE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000379519400005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374703 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xie, Zhigang |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Northeast Normal Univ, Dept Chem, 5628 Renmin St, Changchun 130024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Xiaohua,Li, Zhensheng,Chen, Li,et al. Self-assembly of porphyrin-paclitaxel conjugates into nanomedicines: enhanced cytotoxicity due to endosomal escape[J]. Chemistry-an asian journal,2016,11(12):1780-1784. |
| APA | Zheng, Xiaohua,Li, Zhensheng,Chen, Li,Xie, Zhigang,&Jing, Xiabin.(2016).Self-assembly of porphyrin-paclitaxel conjugates into nanomedicines: enhanced cytotoxicity due to endosomal escape.Chemistry-an asian journal,11(12),1780-1784. |
| MLA | Zheng, Xiaohua,et al."Self-assembly of porphyrin-paclitaxel conjugates into nanomedicines: enhanced cytotoxicity due to endosomal escape".Chemistry-an asian journal 11.12(2016):1780-1784. |
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来源：中国科学院大学
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