Designed synthesis of multi-functional pegylated yb2o3:gd@sio2@ceo2 islands core@shell nanostructure
文献类型：期刊论文
| 作者 | Li, Junqi1,2; Yao, Shuang1; Song, Shuyan1; Wang, Xiao1; Wang, Yinghui1; Ding, Xing3; Wang, Fan1,2; Zhang, Hongjie1 |
| 刊名 | Dalton transactions
 |
| 出版日期 | 2016 |
| 卷号 | 45期号:28页码:11522-11527 |
| ISSN号 | 1477-9226 |
| DOI | 10.1039/c6dt02044e |
| 通讯作者 | Yao, shuang(yaoshuang@ciac.ac.cn) |
| 英文摘要 | Nanomaterials that can restrain or reduce the production of excessive reactive oxygen species such as h2o2 to defend and treat against alzheimer's disease (ad) have attracted much attention. in this paper, we adopt the strategy of layer-by-layer deposition; namely, first synthesizing available gadolinium-doped ytterbia nanoparticles (yb2o3:gd nps) as cores, and then coating them with silica via the classical stober method to prevent leakage and act as a carrier for subsequent ceria deposition and pegylation, and finally obtain the expected core@shell-structured nanocomposite of pegylated yb2o3:gd@sio2@ceo2 islands. the nanomaterial has proved not only to be a high-performance dual-modal contrast agent for use in mri and ct, but also to exhibit excellent catalase mimetic activity, which may help the prognosis, diagnosis and treatment of ad in the future. in addition, scanning electron microscopy (sem), transmission electron microscopy (tem), energy dispersive spectroscopy (eds), x-ray diffraction (xrd), x-ray photoelectron spectroscopy (xps), and fourier transform infrared (ftir) spectroscopy characterization have revealed the successful design and synthesis of the cores with remarkable size uniformity, with well-distributed ceo2 islands decorated on the surface of sio2 shells, and tightly immobilized peg. |
| WOS关键词 | IN-VIVO ; MAGNETIC-RESONANCE ; COMPUTED-TOMOGRAPHY ; HUMAN-DISEASE ; NANOPARTICLES ; VITRO ; CERIUM ; UCNPS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Inorganic & Nuclear |
| 语种 | 英语 |
| WOS记录号 | WOS:000379573200031 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374705 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yao, Shuang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Jilin Univ, Dept Chem, Changchun 130012, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Junqi,Yao, Shuang,Song, Shuyan,et al. Designed synthesis of multi-functional pegylated yb2o3:gd@sio2@ceo2 islands core@shell nanostructure[J]. Dalton transactions,2016,45(28):11522-11527. |
| APA | Li, Junqi.,Yao, Shuang.,Song, Shuyan.,Wang, Xiao.,Wang, Yinghui.,...&Zhang, Hongjie.(2016).Designed synthesis of multi-functional pegylated yb2o3:gd@sio2@ceo2 islands core@shell nanostructure.Dalton transactions,45(28),11522-11527. |
| MLA | Li, Junqi,et al."Designed synthesis of multi-functional pegylated yb2o3:gd@sio2@ceo2 islands core@shell nanostructure".Dalton transactions 45.28(2016):11522-11527. |
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来源：中国科学院大学
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