Time-programmed dca and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery
文献类型：期刊论文
| 作者 | Zhang, Zhiyun1,2; Liu, Shi1; Qi, Yanxin1; Zhou, Dongfang1; Xie, Zhigang1; Jing, Xiabin1; Chen, Xuesi3; Huang, Yubin1 |
| 刊名 | Journal of controlled release
 |
| 出版日期 | 2016-08-10 |
| 卷号 | 235页码:125-133 |
| 关键词 | Local cancer recurrence Local treatment Multilayered electrospun nanofibers Time-programmed release Dichloroacetate Oxaliplatin |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2016.05.046 |
| 通讯作者 | Zhou, dongfang(east@ciac.ac.cn) |
| 英文摘要 | Local recurrence following surgery in cancer treatment remains a major clinical challenge. to increase antitumor activity but maintain toxicity in an acceptable level in prevention of local cancer recurrence, we demonstrated a dual drug-loaded multilayered fiber mats strategy, in which dca and oxaliplatin were co-electrospun into the distinct layer of resultant fabrics and the oxaliplatin-loaded fibers layer was sealed between the basement film layer and other two fibers layers. the dual drug-loaded multilayered fiber mats exhibit time-programmed dual release behavior and synergistic effect upon cancer cells. nontoxic dca selectively promotes apoptosis of cancer cells through modulating cellular metabolism, and oxaliplatin subsequently kills the remained cancer cells in a low concentration. after implantation on the resection margin of cervical carcinoma on a murine model, the dual drug-loaded multilayered fiber mats displayed enhanced anti-recurrence efficacy and decreased side toxic effects over 30 days compared with drug-loaded monolayered fiber mats. the time-programmed combination of dca and oxaliplatin within multilayered nanofiber mats appears to be a promising strategy for local cancer treatment following resection. (c) 2016 elsevier b.v. all rights reserved. |
| WOS关键词 | CELL LUNG-CANCER ; CARCINOMA ; MESHES ; CISPLATIN ; DELIVERY ; NANOPARTICLES ; CHEMOTHERAPY ; STRATEGIES ; APOPTOSIS ; SCAFFOLD |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000379702700012 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374709 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, Dongfang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Ecomat, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhiyun,Liu, Shi,Qi, Yanxin,et al. Time-programmed dca and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery[J]. Journal of controlled release,2016,235:125-133. |
| APA | Zhang, Zhiyun.,Liu, Shi.,Qi, Yanxin.,Zhou, Dongfang.,Xie, Zhigang.,...&Huang, Yubin.(2016).Time-programmed dca and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery.Journal of controlled release,235,125-133. |
| MLA | Zhang, Zhiyun,et al."Time-programmed dca and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery".Journal of controlled release 235(2016):125-133. |
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来源：中国科学院大学
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