Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry
文献类型：期刊论文
| 作者 | Jia, Lewen1,2; Chen, Jing1; Yin, Peiyuan1; Lu, Xin1; Xu, Guowang1 |
| 刊名 | metabolomics
 |
| 出版日期 | 2008-06-01 |
| 卷号 | 4期号:2页码:183-189 |
| 关键词 | metabonomics UPLC Q TOF MS chronic renal failure biomarker |
| 产权排序 | 1;1 |
| 通讯作者 | 许国旺 |
| 英文摘要 | a metabonomics technique based on ultra-performance liquid chromatography (uplc) coupled with q-tof mass spectrometry was employed to investigate the sera from 32 patients with chronic renal failure (crf) without renal replacement therapy and 30 healthy volunteers in order to find potential disease biomarkers and reveal its pathophysiological changes. after data acquisition waters markerlynx software was used to report retention time and m/z pairs for each metabolite peak, these data were exported to an excel table, then handled by using multivariate analysis and the statistical analysis in the simca-p and the spss softwares to obtain potential biomarkers which were further identified by ms/ms. seven potential biomarkers, creatinine, tryptophan, phenylalanine, kynurenine and three lysophosphatidylcholines, were identified. the results suggest that crf can lead to the increase of reservation of creatinine in the body, and the abnormal metabolism of the two essential amino acids and lysophosphatidylcholines. it has indicated that metabonomics will be a powerful tool in the clinic research. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | endocrinology & metabolism |
| 研究领域[WOS] | endocrinology & metabolism |
| 关键词[WOS] | chronic kidney-disease ; nmr-spectroscopy ; inborn-errors ; metabolism ; prevalence ; kynurenine ; biomarkers ; pathway ; plasma ; blood |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000255680200009 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/100443]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China 2.Dalian Univ Med, Affiliated Hosp 1, Dept Nephrol, Dalian 116011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Lewen,Chen, Jing,Yin, Peiyuan,et al. Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry[J]. metabolomics,2008,4(2):183-189. |
| APA | Jia, Lewen,Chen, Jing,Yin, Peiyuan,Lu, Xin,&Xu, Guowang.(2008).Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry.metabolomics,4(2),183-189. |
| MLA | Jia, Lewen,et al."Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry".metabolomics 4.2(2008):183-189. |
入库方式： OAI收割
来源：大连化学物理研究所
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