中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis

文献类型:期刊论文

作者Gao, Peng2; Lu, Chen1; Zhang, Fengxia2,4; Sang, Ping2,3; Yang, Dawei2,3; Li, Xiang2; Kong, Hongwei2; Yin, Peiyuan2; Tian, Jing2,3; Lu, Xin2
刊名analyst
出版日期2008-09-01
卷号133期号:9页码:1214-1220
产权排序1;1
通讯作者许国旺
英文摘要ankylosing spondylitis (as) is a chronic inflammatory arthritis that predominantly affects the axial skeleton in adolescent patients. the natural history of the disease remains poorly characterized. in this study, we combined gc-ms and lc-ms techniques to evaluate the major metabolic changes in the plasma of as patients in view of metabonomics. univariate and multivariate analysis were employed for altered metabolite comparison and pattern recognition. application of supervised partial least-squares discrminant analysis to either gc-ms or lc-ms data allowed accurate discrimination of as patients from normal controls, demonstrating its potential diagnostic utilization. in addition, as patients presented elevated plasma concentrations of proline, glucose, phosphate, urea, glycerol, phenylalanine and homocysteine but reduced levels of phosphocholines, tryptophan and a bipeptide - phenylalanyl-phenylalanine. in the context of their involved metabolic pathways, the identified metabolites were discussed accordingly. this investigation primarily proved that integrated chromatography-mass spectrometry and integrated uni- and multi-variate statistical analysis facilitated metabonomics to be a more promising tool in disease research.
WOS标题词science & technology ; physical sciences
类目[WOS]chemistry, analytical
研究领域[WOS]chemistry
关键词[WOS]chromatography-mass spectrometry ; research-and-development ; bone-mineral density ; systems biology ; metabolic interactions ; rheumatoid-arthritis ; biochemical markers ; endothelial-cells ; gene-expression ; cultured human
收录类别SCI
原文出处true
语种英语
WOS记录号WOS:000259449400014
公开日期2010-11-30
源URL[http://159.226.238.44/handle/321008/100453]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
作者单位1.China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
3.Dalian Polytech Univ, Dept Modern Technol, Dalian 116034, Peoples R China
4.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714
Gao, Peng,Lu, Chen,Zhang, Fengxia,et al. Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis[J]. analyst,2008,133(9):1214-1220.
APA Gao, Peng.,Lu, Chen.,Zhang, Fengxia.,Sang, Ping.,Yang, Dawei.,...&Xu, Guowang.(2008).Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis.analyst,133(9),1214-1220.
MLA Gao, Peng,et al."Integrated GC-MS and LC-MS plasma metabonomics analysis of ankylosing spondylitis".analyst 133.9(2008):1214-1220.

入库方式: OAI收割

来源:大连化学物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。