Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol a and tetrachlorobisphenol a
文献类型：期刊论文
| 作者 | Ye, Guozhu1; Chen, Yajie1,2; Wang, Hong-ou1,2; Ye, Ting1,2; Lin, Yi1; Huang, Qiansheng1; Chi, Yulang1; Dong, Sijun1 |
| 刊名 | Scientific reports
 |
| 出版日期 | 2016-10-13 |
| 卷号 | 6页码:11 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep35257 |
| 通讯作者 | Dong, sijun(sjdong@iue.ac.cn) |
| 英文摘要 | Tetrabromobisphenol a and tetrachlorobisphenol a are halogenated bisphenol a (h-bpa), and has raised concerns about their adverse effects on the development of fetuses and infants, however, the molecular mechanisms are unclear, and related metabolomics studies are limited. accordingly, a metabolomics study based on gas chromatography-mass spectrometry was employed to elucidate the molecular developmental toxicology of h-bpa using the marine medaka (oryzias melastigmas) embryo model. here, we revealed decreased synthesis of nucleosides, amino acids and lipids, and disruptions in the tca (tricarboxylic acid) cycle, glycolysis and lipid metabolism, thus inhibiting the developmental processes of embryos exposed to h-bpa. unexpectedly, we observed enhanced neural activity accompanied by lactate accumulation and accelerated heart rates due to an increase in dopamine pathway and a decrease in inhibitory neurotransmitters following h-bpa exposure. notably, disorders of the neural system, and disruptions in glycolysis, the tca cycle, nucleoside metabolism, lipid metabolism, glutamate and aspartate metabolism induced by h-bpa exposure were heritable. furthermore, lactate and dopa were identified as potential biomarkers of the developmental toxicity of h-bpa and related genetic effects. this study has demonstrated that the metabolomics approach is a useful tool for obtaining comprehensive and novel insights into the molecular developmental toxicity of environmental pollutants. |
| WOS关键词 | BROMINATED FLAME-RETARDANTS ; ZEBRAFISH DANIO-RERIO ; BISPHENOL-A ; EXPOSURE ASSESSMENT ; ORYZIAS-MELASTIGMA ; NEURON DEVELOPMENT ; GABA(A) RECEPTORS ; PANIC DISORDER ; BRAIN LACTATE ; ANXIETY |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000385344600001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374771 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dong, Sijun |
| 作者单位 | 1.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Guozhu,Chen, Yajie,Wang, Hong-ou,et al. Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol a and tetrachlorobisphenol a[J]. Scientific reports,2016,6:11. |
| APA | Ye, Guozhu.,Chen, Yajie.,Wang, Hong-ou.,Ye, Ting.,Lin, Yi.,...&Dong, Sijun.(2016).Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol a and tetrachlorobisphenol a.Scientific reports,6,11. |
| MLA | Ye, Guozhu,et al."Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol a and tetrachlorobisphenol a".Scientific reports 6(2016):11. |
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来源：中国科学院大学
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