Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry
文献类型：期刊论文
| 作者 | Zhao, Xinjie; Zhang, Yi2; Meng, Xianli2; Yin, Peiyuan; Deng, Chong2; Chen, Jing; Wang, Zhang2; Xu, Guowang1 |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 873期号:2页码:151-158 |
| 关键词 | Sea buckthorn Metabonomics Urine UPLC Q-TOF MS Biomarker Acute blood stasis |
| 产权排序 | 1;1 |
| 通讯作者 | 许国旺 |
| 英文摘要 | xindi soft capsule is a traditional chinese medicine preparation which consists of sea buckthorn flavonoids and sea buckthorn berry oil. in this study, a urinary metabonomics method based on the ultra-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (uplc q-tof ms) was used to evaluate the efficacy and study the mechanism of traditional chinese medicine preparation to blood stasis. with pattern recognition analysis (principal component analysis and partial least squares-discriminate analysis) of urinary metabolites, a clear separation of acute blood stasis model group and healthy control group was achieved, the dose groups were located between acute blood stasis model group and healthy control group showing a tendency of recovering to healthy control group, high dose and middle dose were more effective than low dose. some significantly changed metabolites like cholic acid. phenylalanine and kynurenic acid have been found and identified and used to explain the mechanism. the work shows that the metabonomics method is a valuable tool in the research mechanism of traditional chinese medicine. (c) 2008 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | multivariate statistical-analysis ; hippophae-rhamnoides-l ; uplc-ms ; cardiovascular-disease ; platelet-aggregation ; kynurenine pathway ; discovery ; metabolism ; disorders ; risk |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000260196000004 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/100461]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Chengdu Univ Tradit Chinese Med, Chengdu 610031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Xinjie,Zhang, Yi,Meng, Xianli,et al. Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2008,873(2):151-158. |
| APA | Zhao, Xinjie.,Zhang, Yi.,Meng, Xianli.,Yin, Peiyuan.,Deng, Chong.,...&Xu, Guowang.(2008).Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry.journal of chromatography b-analytical technologies in the biomedical and life sciences,873(2),151-158. |
| MLA | Zhao, Xinjie,et al."Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: A urinary metabonomics study based on liquid chromatography-mass spectrometry".journal of chromatography b-analytical technologies in the biomedical and life sciences 873.2(2008):151-158. |
入库方式： OAI收割
来源：大连化学物理研究所
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