Ifn-lambda 4 desensitizes the response to ifn-alpha treatment in chronic hepatitis c through long-term induction of usp18
文献类型：期刊论文
| 作者 | Fan, Weiguo1; Xie, Shiqi1,5; Zhao, Xinhao1; Li, Nan1,2; Chang, Chong1; Li, Li1; Yu, Ge3; Chi, Xiumei3; Pan, Yu3; Niu, Junqi3 |
| 刊名 | Journal of general virology
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 97页码:2210-2220 |
| ISSN号 | 0022-1317 |
| DOI | 10.1099/jgv.0.000522 |
| 通讯作者 | Niu, junqi(junqiniu@aliyun.com) ; Zhong, jin(jzhong@sibs.ac.cn) ; Sun, bing(bsun@sibs.ac.cn) |
| 英文摘要 | The recently discovered interferon lambda 4 (ifn-lambda 4) is a new member of the human type iii interferons which could induce a strong antiviral effect through the jak-stat cascade. however, hepatitis c virus (hcv) patients who are capable of expressing ifn-lambda 4 usually have poor response to ifn-alpha treatment, and the mechanism behind this paradox remains unknown. here, we reported that ifn-lambda 4 desensitized ifn-alpha-stimulated jak-stat signalling. microarray analysis revealed that ifn-lambda 4 could induce ubiquitin specific peptidase 18 (usp18), a known inhibitor of the type i ifn signalling pathway, in a more sustained pattern compared with type i interferon induction. moreover, only hcv genotype 1b but not 2a replicon cells pretreated with ifn-lambda 4 had an attenuated response to type i ifn treatment, which might be due to the different level of usp18 expression. consistently, knockdown of usp18 in hcv genotype 1b-containing replicon cells reversed the resistance induced by ifn-lambda 4 and promoted viral clearance. finally, ifn-lambda 4 is also strongly associated with the poor response to ifn-alpha in a chinese hcv genotype 1b cohort. in conclusion, these data indicate that ifn-lambda 4 attenuates the response of hcv genotype 1b to ifn-alpha therapy and inhibits the jak-stat signalling pathway by inducing usp18 expression. |
| WOS关键词 | HUMAN-LEUKOCYTE INTERFERON ; JAK-STAT PATHWAY ; VIRUS-REPLICATION ; INFECTION ; LAMBDA ; HEPATOCYTES ; CELLS ; HCV ; IDENTIFICATION ; EXPRESSION |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Virology |
| WOS类目 | Biotechnology & Applied Microbiology ; Virology |
| 语种 | 英语 |
| 出版者 | MICROBIOLOGY SOC |
| WOS记录号 | WOS:000385291700018 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374813 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Niu, Junqi; Zhong, Jin; Sun, Bing |
| 作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Mol Virol & Immunol,Inst Pasteur Shanghai, Shanghai 200031, Peoples R China 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 3.Jilin Univ, Hosp 1, Hepatol Sect, Changchun 130021, Jilin, Peoples R China 4.Inst Biochem & Cell Biol, Lab Mol Cell Biol, Shanghai, Peoples R China 5.Univ Texas Southwestern Med Ctr Dallas, Dept Obstet & Gynecol, Cecil H & Ida Green Ctr Reprod Biol Sci, Dallas, TX 75390 USA |
| 推荐引用方式 GB/T 7714 | Fan, Weiguo,Xie, Shiqi,Zhao, Xinhao,et al. Ifn-lambda 4 desensitizes the response to ifn-alpha treatment in chronic hepatitis c through long-term induction of usp18[J]. Journal of general virology,2016,97:2210-2220. |
| APA | Fan, Weiguo.,Xie, Shiqi.,Zhao, Xinhao.,Li, Nan.,Chang, Chong.,...&Sun, Bing.(2016).Ifn-lambda 4 desensitizes the response to ifn-alpha treatment in chronic hepatitis c through long-term induction of usp18.Journal of general virology,97,2210-2220. |
| MLA | Fan, Weiguo,et al."Ifn-lambda 4 desensitizes the response to ifn-alpha treatment in chronic hepatitis c through long-term induction of usp18".Journal of general virology 97(2016):2210-2220. |
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来源：中国科学院大学
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