Preparation and self-assembly of ph-sensitive amphiphilic comb-shaped copolymer containing long fluorinated side chains
文献类型：期刊论文
| 作者 | Tan, Jianquan1,2,3; Liu, Weiqu1,2; Wang, Zhengfang1,2 |
| 刊名 | Journal of macromolecular science part a-pure and applied chemistry
 |
| 出版日期 | 2016 |
| 卷号 | 53期号:11页码:716-724 |
| 关键词 | Ph-sensitive Amphiphilic comb-shaped copolymer Self-assembly Fluorinated side chains Cytotoxicity |
| ISSN号 | 1060-1325 |
| DOI | 10.1080/10601325.2016.1224630 |
| 通讯作者 | Liu, weiqu(liuwq@gic.ac.cn) |
| 英文摘要 | Novel ph-sensitive amphiphilic comb-shaped copolymers containing long fluorinated side chains, which combined the characteristics of ph-sensitivity from pendent tertiary amine groups, unique hydrophobic and fluorophobic characteristic from the fluorinated moieties and hydrophilicity from the poly (ethylene glycol) segments, were designed and synthesized via radical polymerizaion of 2-(dimethylamino) ethyl methacrylate (dmaema), poly (ethylene glycol) methyl ether methacrylate (pegma) and homemade fluorinated macromonomer (phfbma-gma). the physicochemical properties of polymeric micelles prepared therefrom were investigated. the chemical structures of the copolymers were characterized by gpc, ftir and h-1-nmr. the critical micelle concentrations (cmc) of the copolymers in different ph (5.0 and 7.4) were determined by fluorescence spectroscopy. larger cmcs could be obtained in lower ph since the pronation of dmaema moieties enhanced the hydrophilicity. with increasing the amount, as well as the molecular weight, of phfbma-gma, cmc decreased significantly. as ph decreased, particle size, as well as zeta potential of the polymeric micelles increased significantly, indicating significant ph-sensitivity of the polymeric micelles. furthermore, larger polymeric micelles were obtained with larger amount, as well as higher molecular weight, of phfbma-gma. transmission electron microscopy (tem) showed that the morphological shapes of the copolymers performed spherical micelles. the cytotoxicity test showed that the comb-shaped copolymers performed extremely low cytotoxicity. the ph-sensitive polymeric micelles prepared from the amphiphilic comb-shaped copolymers containing long fluorinated side chains could be potential candidates for nanotanks for hydrophobic or fluorophobic molecules and drug carriers and the facile preparation might fit for large scale industrialization. |
| WOS关键词 | LOW SURFACE-ENERGY ; GRAFT-COPOLYMERS ; HYDROPHOBIC BACKBONE ; HYDROPHILIC BRANCHES ; METHACRYLATE)-G-POLY(METHYL METHACRYLATE) ; BLOCK-COPOLYMERS ; AQUEOUS-SOLUTION ; DRUG-DELIVERY ; MICELLES ; POLYMERIZATION |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000385564600009 |
| 出版者 | TAYLOR & FRANCIS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374824 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Weiqu |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Chem, Guangzhou 510650, Guangdong, Peoples R China 2.Chinese Acad Sci, Key Lab Cellulose & Lignocellulos Chem, Guangzhou, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, Jianquan,Liu, Weiqu,Wang, Zhengfang. Preparation and self-assembly of ph-sensitive amphiphilic comb-shaped copolymer containing long fluorinated side chains[J]. Journal of macromolecular science part a-pure and applied chemistry,2016,53(11):716-724. |
| APA | Tan, Jianquan,Liu, Weiqu,&Wang, Zhengfang.(2016).Preparation and self-assembly of ph-sensitive amphiphilic comb-shaped copolymer containing long fluorinated side chains.Journal of macromolecular science part a-pure and applied chemistry,53(11),716-724. |
| MLA | Tan, Jianquan,et al."Preparation and self-assembly of ph-sensitive amphiphilic comb-shaped copolymer containing long fluorinated side chains".Journal of macromolecular science part a-pure and applied chemistry 53.11(2016):716-724. |
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来源：中国科学院大学
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