Eplerenone inhibits atrial fibrosis in mutant tgf-beta 1 transgenic mice
文献类型：期刊论文
| 作者 | Chen, Xiaoqing1; Zhang, Wuchang2; Wang, Qian1; Du, Lili1; Yi, Yi1; Liu, Yan2; Liu, Xu1; Duan, Shengzhong2 |
| 刊名 | Science china-life sciences
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 59期号:10页码:1042-1047 |
| ISSN号 | 1674-7305 |
| 关键词 | Eplerenone Atrial fibrosis Atrial fibroblasts Macrophages Tgf-beta 1 |
| DOI | 10.1007/s11427-016-0037-y |
| 通讯作者 | Liu, xu(xkliuxu@126.com) ; Duan, shengzhong(szduan@sibs.ac.cn) |
| 英文摘要 | The purpose of the present study was to study the impacts of eplerenone (epl), an antagonist of mineralocorticoid receptors (mr), on atrial fibrosis in a mouse model with selective fibrosis in the atrium, and to explore the possible mechanisms. using mutant tgf-beta 1 transgenic (tx) mice, we first demonstrated that epl inhibited atrial fibrosis specifically and decreased macrophage accumulation in the atria of these mice. results from immunohistochemistry and western blotting showed that epl attenuated protein expression of fibrosis-related molecules such as connective tissue growth factor (ctgf) and fibronectin in the atria of tx mice. in culture, epl inhibited gene expression of fibrosis-related molecules such as fibronectin, alpha-sma, and ctgf in tgf-beta 1-stimulated atrial fibroblasts. finally, using a co-culture system, we showed that tgf-beta 1-stimulated atrial fibroblasts induced migration of macrophages and this was blocked by epl. epl also blocked tgf-beta 1-induced gene expression of intedeukin-6 (il-6) in atrial fibroblasts. therefore, we conclude that epl attenuated atrial fibrosis and macrophage infiltration in tx mice. tgf-beta 1 and il-6 were involved in the impacts of epl on activation of atrial fibroblasts and interactions between fibroblasts and macrophages. |
| WOS关键词 | FIBRILLATION |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000385416200007 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374840 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Xu; Duan, Shengzhong |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Cardiol, Shanghai 200030, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Xiaoqing,Zhang, Wuchang,Wang, Qian,et al. Eplerenone inhibits atrial fibrosis in mutant tgf-beta 1 transgenic mice[J]. Science china-life sciences,2016,59(10):1042-1047. |
| APA | Chen, Xiaoqing.,Zhang, Wuchang.,Wang, Qian.,Du, Lili.,Yi, Yi.,...&Duan, Shengzhong.(2016).Eplerenone inhibits atrial fibrosis in mutant tgf-beta 1 transgenic mice.Science china-life sciences,59(10),1042-1047. |
| MLA | Chen, Xiaoqing,et al."Eplerenone inhibits atrial fibrosis in mutant tgf-beta 1 transgenic mice".Science china-life sciences 59.10(2016):1042-1047. |
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来源：中国科学院大学
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