Spatiotemporal control of cell-cell reversible interactions using molecular engineering
文献类型：期刊论文
| 作者 | Shi, Peng1,2,3; Ju, Enguo1,2,3; Yan, Zhengqing1,2,3; Gao, Nan1,2; Wang, Jiasi1,2,3; Hou, Jianwen3; Zhang, Yan4; Ren, Jinsong1,2; Qu, Xiaogang1,2 |
| 刊名 | Nature communications
 |
| 出版日期 | 2016-10-06 |
| 卷号 | 7页码:9 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/ncomms13088 |
| 通讯作者 | Qu, xiaogang(xqu@ciac.ac.cn) |
| 英文摘要 | Manipulation of cell-cell interactions has potential applications in basic research and cell-based therapy. herein, using a combination of metabolic glycan labelling and bio-orthogonal click reaction, we engineer cell membranes with beta-cyclodextrin and subsequently manipulate cell behaviours via photo-responsive host-guest recognition. with this methodology, we demonstrate reversible manipulation of cell assembly and disassembly. the method enables light-controllable reversible assembly of cell-cell adhesion, in contrast with previously reported irreversible effects, in which altered structure could not be reused. we also illustrate the utility of the method by designing a cell-based therapy. peripheral blood mononuclear cells modified with aptamer are effectively redirected towards target cells, resulting in enhanced cell apoptosis. our approach allows precise control of reversible cell-cell interactions and we expect that it will promote further developments of cell-based therapy. |
| WOS关键词 | CLICK CHEMISTRY ; LIVE CELLS ; ADHESION ; DNA ; SURFACES ; DELIVERY ; RELEASE ; RECOGNITION ; CAPTURE ; GLYCANS |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| 出版者 | NATURE PUBLISHING GROUP |
| WOS记录号 | WOS:000385557200001 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374849 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Qu, Xiaogang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Jilin Univ, Coll Iife Sci, Changchun 130012, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Peng,Ju, Enguo,Yan, Zhengqing,et al. Spatiotemporal control of cell-cell reversible interactions using molecular engineering[J]. Nature communications,2016,7:9. |
| APA | Shi, Peng.,Ju, Enguo.,Yan, Zhengqing.,Gao, Nan.,Wang, Jiasi.,...&Qu, Xiaogang.(2016).Spatiotemporal control of cell-cell reversible interactions using molecular engineering.Nature communications,7,9. |
| MLA | Shi, Peng,et al."Spatiotemporal control of cell-cell reversible interactions using molecular engineering".Nature communications 7(2016):9. |
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来源：中国科学院大学
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