A raft copolymerization of nipam and hpma and evaluation of thermo-responsive properties of poly(nipam-co-hpma)
文献类型：期刊论文
| 作者 | Luan, Bao1,2,3; Muir, Benjamin W.1; Zhu, Jin2; Hao, Xiaojuan1 |
| 刊名 | Rsc advances
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:92页码:89925-89933 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c6ra22722h |
| 通讯作者 | Hao, xiaojuan(xiaojuan.hao@csiro.au) |
| 英文摘要 | Poly(n-isopropylacrylamide) (pnipam) has attracted intensive interest for bio-medical applications due to its unique thermal properties whereby it displays a lower critical solution temperature (lcst) close to body temperature. it is well known that the lcst of pnipam can be tuned by incorporating a second component. in this study, a library of (co)polymers of nipam and n-(2-hydroxypropyl) methacrylamide (hpma) with varying molecular weight (mw), composition, and end functionality were synthesized by reversible addition-fragmentation chain transfer (raft) polymerization to systematically investigate how these factors influence their thermo-responsive behavior. our findings include: (1) the lcst of nipam-co-hpma (co) polymers increases with hpma content (fhpma) in the temperature range from 29 to 92 degrees c; (2) the lcst of the polymers is significantly higher when the hydrophobic dithiobenzoate end-group is converted to a thiol-group, however, this influence becomes less pronounced for high mw polymers; (3) the mw of the copolymers has a negligible influence on the lcst. this systematic study investigating the effects of such influencing factors as mw, end group, and polymer composition on the lcst of nipam-containing polymers provides new insights into this class of thermo-responsive polymers. |
| WOS关键词 | TRANSFER RADICAL POLYMERIZATION ; CRITICAL SOLUTION TEMPERATURE ; N-ISOPROPYLACRYLAMIDE ; MOLECULAR-WEIGHT ; THERMOSENSITIVE POLYMER ; DRUG-RELEASE ; AQUEOUS-SOLUTIONS ; BLOCK-COPOLYMERS ; PHASE-TRANSITION ; THERMAL RESPONSE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000384441200118 |
| 出版者 | ROYAL SOC CHEMISTRY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374856 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hao, Xiaojuan |
| 作者单位 | 1.CSIRO Mfg, Clayton, Vic 3168, Australia 2.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 3.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luan, Bao,Muir, Benjamin W.,Zhu, Jin,et al. A raft copolymerization of nipam and hpma and evaluation of thermo-responsive properties of poly(nipam-co-hpma)[J]. Rsc advances,2016,6(92):89925-89933. |
| APA | Luan, Bao,Muir, Benjamin W.,Zhu, Jin,&Hao, Xiaojuan.(2016).A raft copolymerization of nipam and hpma and evaluation of thermo-responsive properties of poly(nipam-co-hpma).Rsc advances,6(92),89925-89933. |
| MLA | Luan, Bao,et al."A raft copolymerization of nipam and hpma and evaluation of thermo-responsive properties of poly(nipam-co-hpma)".Rsc advances 6.92(2016):89925-89933. |
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来源：中国科学院大学
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