Contribution of intertwined loop to membrane association revealed by zika virus full-length ns1 structure
文献类型：期刊论文
| 作者 | Xu, Xiaoying1,2; Song, Hao2,3; Qi, Jianxun2,4; Liu, Yuqian2,5; Wang, Haiyuan2,6; Su, Chao2,7; Shi, Yi2,4,8; Gao, George F.1,2,3,4,8,9 |
| 刊名 | Embo journal
 |
| 出版日期 | 2016-10-17 |
| 卷号 | 35期号:20页码:2170-2178 |
| 关键词 | Crystal structure Membrane association Ns1 Zika virus |
| ISSN号 | 0261-4189 |
| DOI | 10.15252/embj.201695290 |
| 通讯作者 | Shi, yi(shiyi@im.ac.cn) ; Gao, george f.(gaof@im.ac.cn) |
| 英文摘要 | The association of zika virus (zikv) infections with microcephaly and neurological diseases has highlighted an emerging public health concern. here, we report the crystal structure of the full-length zikv nonstructural protein 1 (ns1), a major host-interaction molecule that functions in flaviviral replication, pathogenesis, and immune evasion. of note, a long intertwined loop is observed in the wing domain of zikv ns1, and forms a hydrophobic "spike", which can contribute to cellular membrane association. for different flaviviruses, the amino acid sequences of the "spike" are variable but their common characteristic is either hydrophobic or positively charged, which is a beneficial feature for membrane binding. comparative studies with west nile and dengue virus ns1 structures reveal conserved features, but diversified electrostatic characteristics on both inner and outer faces. our results suggest different mechanisms of flavivirus pathogenesis and should be considered during the development of diagnostic tools. |
| WOS关键词 | NONSTRUCTURAL PROTEIN NS1 ; WEST-NILE-VIRUS ; DENGUE VIRUS ; COMPLEMENT ACTIVATION ; MAXIMUM-LIKELIHOOD ; GLYCOPROTEIN NS1 ; RNA REPLICATION ; ANTIBODIES ; MICE ; INFECTION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000385708000002 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374878 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shi, Yi; Gao, George F. |
| 作者单位 | 1.Univ Sci & Technol China, Sch Life Sci, Hefei, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 3.Chinese Acad Sci, Beijing Inst Life Sci, RNIH, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China 5.Anhui Univ, Inst Hlth Sci, Hefei, Peoples R China 6.Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China 7.China Agr Univ, Coll Vet Med, Beijing, Peoples R China 8.Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing, Peoples R China 9.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Xiaoying,Song, Hao,Qi, Jianxun,et al. Contribution of intertwined loop to membrane association revealed by zika virus full-length ns1 structure[J]. Embo journal,2016,35(20):2170-2178. |
| APA | Xu, Xiaoying.,Song, Hao.,Qi, Jianxun.,Liu, Yuqian.,Wang, Haiyuan.,...&Gao, George F..(2016).Contribution of intertwined loop to membrane association revealed by zika virus full-length ns1 structure.Embo journal,35(20),2170-2178. |
| MLA | Xu, Xiaoying,et al."Contribution of intertwined loop to membrane association revealed by zika virus full-length ns1 structure".Embo journal 35.20(2016):2170-2178. |
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来源：中国科学院大学
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