Interactions of graphene with mammalian cells: molecular mechanisms and biomedical insights
文献类型：期刊论文
| 作者 | Zhang, Bo1; Wei, Peng1,2; Zhou, Zhixiang3; Wei, Taotao1 |
| 刊名 | Advanced drug delivery reviews
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 105页码:145-162 |
| 关键词 | Graphene Lysosome Mitochondria Metabolism Cancer therapy Biomedicine Interaction Intracellular components |
| ISSN号 | 0169-409X |
| DOI | 10.1016/j.addr.2016.08.009 |
| 通讯作者 | Wei, taotao(weitt@moon.ibp.ac.cn) |
| 英文摘要 | Carbon-based functional nanomaterials have attracted immense scientific interest from many disciplines and, due to their extraordinary properties, have offered tremendous potential in a diverse range of applications. among the different carbon nanomaterials, graphene is one of the newest and is considered the most important. graphene, a monolayer material composed of sp(2)-hybridized carbon atoms hexagonally arranged in a two-dimensional structure, can be easily functionalized by chemical modification. functionalized graphene and its derivatives have been used in diverse nano-biotechnological applications, such as in environmental engineering, biomedicine, and biotechnology. however, the prospective use of graphene-related materials in a biological context requires a detailed comprehension of these materials, which is essential for expanding their biomedical applications in the future. in recent years, the number of biological studies involving graphene-related nanomaterials has rapidly increased. these studies have documented the effects of the biological interactions between graphene-related materials and different organizational levels of living systems, ranging from biomolecules to animals. in the present review, we will summarize the recent progress in understanding mainly the interactions between graphene and cells. the impact of graphene on intracellular components, and especially the uptake and transport of graphene by cells, will be discussed in detail. (c) 2016 the authors. published by elsevier b.v. this is an open access article under the cc by-nc-nd license. |
| WOS关键词 | CELLULAR INTERNALIZATION PATHWAYS ; MESENCHYMAL STEM-CELLS ; DRUG-DELIVERY SYSTEM ; OXIDE NANOSHEETS ; SIGNALING PATHWAYS ; CARBON NANOTUBES ; PHOTOTHERMAL THERAPY ; IN-VITRO ; PRISTINE GRAPHENE ; CANCER-CELLS |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000385600900003 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374894 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wei, Taotao |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Univ Technol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Bo,Wei, Peng,Zhou, Zhixiang,et al. Interactions of graphene with mammalian cells: molecular mechanisms and biomedical insights[J]. Advanced drug delivery reviews,2016,105:145-162. |
| APA | Zhang, Bo,Wei, Peng,Zhou, Zhixiang,&Wei, Taotao.(2016).Interactions of graphene with mammalian cells: molecular mechanisms and biomedical insights.Advanced drug delivery reviews,105,145-162. |
| MLA | Zhang, Bo,et al."Interactions of graphene with mammalian cells: molecular mechanisms and biomedical insights".Advanced drug delivery reviews 105(2016):145-162. |
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来源：中国科学院大学
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