Hepatic loss of borealin impairs postnatal liver development, regeneration, and hepatocarcinogenesis
文献类型：期刊论文
| 作者 | Li, Lu1,2; Li, Dan1; Tian, Feng3; Cen, Jin1; Chen, Xiaotao1; Ji, Yuan3; Hui, Lijian1 |
| 刊名 | Journal of biological chemistry
 |
| 出版日期 | 2016-09-30 |
| 卷号 | 291期号:40页码:21137-+ |
| ISSN号 | 0021-9258 |
| DOI | 10.1074/jbc.m116.736173 |
| 通讯作者 | Li, dan(lidan@sibcb.ac.cn) ; Hui, lijian(ljhui@sibcb.ac.cn) |
| 英文摘要 | Borealin, a member of the chromosomal passenger complex, plays a key regulatory role at centromeres and the central spindle during mitosis. loss of borealin leads to defective cell proliferation and early embryonic lethality. the in vivo functions of borealin in mammalian postnatal development, tissue homeostasis, and tumorigenesis remain elusive. we specifically analyzed the role of borealin in regulating postnatal liver development, damage-induced liver regeneration, and liver carcinogenesis using mice carrying conditional borealin alleles. perinatal loss of borealin caused increased genome ploidy and enlarged cell size in hepatocytes, likely due to the impaired function of the chromosomal passenger complex in mitosis. borealin deletion also showed attenuated expansion of sox9(+)hnf4 alpha(+) progenitor-like cells in liver regeneration during 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-inducedliverinjury. moreover, delta n90-beta-catenin and c-met-induced hepatocarcinogenesis development was largely impeded by borealin deletion. these findings indicate that borealin plays a key role in liver development, regeneration, and tumorigenesis and suggests that borealin could be a potential target for related liver diseases. |
| WOS关键词 | PROGENITOR CELLS ; MATURE HEPATOCYTES ; PROMOTES EXPANSION ; CANCER-CELLS ; STEM-CELLS ; SURVIVIN ; PROTEIN ; AURORA ; PROLIFERATION ; TUMORIGENESIS |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000385406200028 |
| 出版者 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374911 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Dan; Hui, Lijian |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Shanghai, Peoples R China 3.Fudan Univ, Zhongshan Hosp, Dept Pathol, Fenglin Rd 180, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Lu,Li, Dan,Tian, Feng,et al. Hepatic loss of borealin impairs postnatal liver development, regeneration, and hepatocarcinogenesis[J]. Journal of biological chemistry,2016,291(40):21137-+. |
| APA | Li, Lu.,Li, Dan.,Tian, Feng.,Cen, Jin.,Chen, Xiaotao.,...&Hui, Lijian.(2016).Hepatic loss of borealin impairs postnatal liver development, regeneration, and hepatocarcinogenesis.Journal of biological chemistry,291(40),21137-+. |
| MLA | Li, Lu,et al."Hepatic loss of borealin impairs postnatal liver development, regeneration, and hepatocarcinogenesis".Journal of biological chemistry 291.40(2016):21137-+. |
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来源：中国科学院大学
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