N-acetylgalactosaminyltransferases in cancer
文献类型：期刊论文
| 作者 | Hussain, Muhammad Ramzan Manwar1,2; Hoessli, Daniel C.3; Fang, Min1 |
| 刊名 | Oncotarget
 |
| 出版日期 | 2016-08-16 |
| 卷号 | 7期号:33页码:54067-54081 |
| 关键词 | N-acetylgalactosaminyltransferases O-linked glycoprotein biosynthesis Cancer markers |
| ISSN号 | 1949-2553 |
| DOI | 10.18632/oncotarget.10042 |
| 通讯作者 | Fang, min(fangm@im.ac.cn) |
| 英文摘要 | Aberrant mucin-type o-glycosylation by glycosyl-transferases is a well-described hallmark of many cancers and is also associated with additional noncancerous developmental and metabolic disorders. the current review focuses on n-acetylgalactosaminyltransferase genes (galnts) and proteins (galnacts) to illustrate their importance in cancer biology. aberrant o-glycosylation by galnacts activates a wide range of proteins that carry out interactions of sessile and motile cells affecting organogenesis, responses to agonists and stimulating hyperproliferation and metastatisation of neoplastic cells. as genome-wide analyses have provided abundant clues regarding under-or over-expressed genes that characterize different types of cancers, galnts and their transferase products have attracted attention by being unexpected actors in neoplastic contexts. we intend to review the current knowledge on galnts and their encoded transferases in cancer and suggest what could be the significance of such information in cancer pathogenesis and management. |
| WOS关键词 | ALPHA-D-GALACTOSAMINE ; GENOME-WIDE ASSOCIATION ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; FAMILIAL TUMORAL CALCINOSIS ; EPITHELIAL OVARIAN-CANCER ; SQUAMOUS-CELL CARCINOMA ; O-GLYCAN BIOSYNTHESIS ; HEPATOCELLULAR-CARCINOMA ; GENE-EXPRESSION ; GALNAC-TRANSFERASE |
| WOS研究方向 | Oncology ; Cell Biology |
| WOS类目 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000385433000108 |
| 出版者 | IMPACT JOURNALS LLC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374912 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Fang, Min |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Univ Karachi, Dr Panjwani Ctr Mol Med & Drug Res, Int Ctr Chem & Biol Sci, Karachi, Pakistan |
| 推荐引用方式 GB/T 7714 | Hussain, Muhammad Ramzan Manwar,Hoessli, Daniel C.,Fang, Min. N-acetylgalactosaminyltransferases in cancer[J]. Oncotarget,2016,7(33):54067-54081. |
| APA | Hussain, Muhammad Ramzan Manwar,Hoessli, Daniel C.,&Fang, Min.(2016).N-acetylgalactosaminyltransferases in cancer.Oncotarget,7(33),54067-54081. |
| MLA | Hussain, Muhammad Ramzan Manwar,et al."N-acetylgalactosaminyltransferases in cancer".Oncotarget 7.33(2016):54067-54081. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。