Optimization of bi3+ in upconversion nanoparticles induced simultaneous enhancement of near-infrared optical and x-ray computed tomography imaging capability
文献类型：期刊论文
| 作者 | Lei, Pengpeng1,2; Zhang, Peng3; Yao, Shuang1; Song, Shuyan1; Dong, Lile1,2; Xu, Xia1,2; Liu, Xiuling1; Du, Kaimin1,2; Feng, Jing1; Zhang, Hongjie1 |
| 刊名 | Acs applied materials & interfaces
 |
| 出版日期 | 2016-10-19 |
| 卷号 | 8期号:41页码:27490-27497 |
| 关键词 | Bi3+ ion Upconversion nanoparticles Nagdf4 Signal enhancement Trimodal imaging |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.6b08335 |
| 通讯作者 | Feng, jing(fengj@ciac.ac.cn) ; Zhang, hongjie(hongjie@ciac.ac.cn) |
| 英文摘要 | Bioimaging probes have been extensive studied for many years, while it is still a challenge to further improve the image quality for precise diagnosis in clinical medicine. here, monodisperse nagdf4:yb3+,tm3+,x% bi3+ (abbreviated as gyt-x% bi3+, x = 0, 5, 10, 15, 20, 25, 30) upconversion nanoparticles (ucnps) have been prepared through the solvothermal method. the near-infrared upconversion emission intensity of gyt-25% bi3+ has been enhanced remarkably than that of nagdf4:yb3+,tm3+ (gyt) with a factor of similar to 60. especially, the near-infrared upconversion emission band centered at 802 nm is 150 times stronger than the blue emission band of gyt-25% bi3+ ucnps. such high ratio of nir/blue ucl intensity could reduce the damage to tissues in the bioimaging process. the possibility of using gyt-25% bi3+ ucnps with strong near-infrared upconversion emission for optical imaging in vitro and in vivo was performed. encouragingly, the ucl imaging penetration depth can be achieved as deep as 20 mm. importantly, gyt-25% bi3+ ucnps exhibit a much higher x-ray computed tomography (ct) contrast efficiency than gyt and iodine-based contrast agent under the same clinical conditions, due to the high x-ray attenuation coefficient of bismuth. hence, simultaneous remarkable enhancement of nir emission and x-ray ct signal in upconversion nanoparticles could be achieved by optimizing the doping concentration of bi3+ ions. additionally, gd3+ ions in the ucnps endow gyt-25% bi3+ ucnps with t1-weighted magnetic resonance (mr) imaging capability. |
| WOS关键词 | BINARY CONTRAST AGENT ; IN-VIVO ; ENERGY-TRANSFER ; CANCER-THERAPY ; NM EXCITATION ; NANOPROBES ; CORE ; NANOCRYSTALS ; PROBES ; LIGHT |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000385992400012 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2374925 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Feng, Jing; Zhang, Hongjie |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, 5625 Renmin St, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Jilin Univ, Hosp 2, Dept Radiol, Changchun 130041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Pengpeng,Zhang, Peng,Yao, Shuang,et al. Optimization of bi3+ in upconversion nanoparticles induced simultaneous enhancement of near-infrared optical and x-ray computed tomography imaging capability[J]. Acs applied materials & interfaces,2016,8(41):27490-27497. |
| APA | Lei, Pengpeng.,Zhang, Peng.,Yao, Shuang.,Song, Shuyan.,Dong, Lile.,...&Zhang, Hongjie.(2016).Optimization of bi3+ in upconversion nanoparticles induced simultaneous enhancement of near-infrared optical and x-ray computed tomography imaging capability.Acs applied materials & interfaces,8(41),27490-27497. |
| MLA | Lei, Pengpeng,et al."Optimization of bi3+ in upconversion nanoparticles induced simultaneous enhancement of near-infrared optical and x-ray computed tomography imaging capability".Acs applied materials & interfaces 8.41(2016):27490-27497. |
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来源：中国科学院大学
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