Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications
文献类型：期刊论文
| 作者 | Li, Ming1,3; Xiong, Pan3; Mo, Maosong1,2; Cheng, Yan3; Zheng, Yufeng3,4 |
| 刊名 | Frontiers of materials science
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 10期号:3页码:270-280 |
| 关键词 | Graphene oxide Silk fibroin Hydroxyapatite Nano-biocomposite coatings Electrodeposition |
| ISSN号 | 2095-025X |
| DOI | 10.1007/s11706-016-0347-7 |
| 通讯作者 | Mo, maosong(msmo@mail.iee.ac.cn) ; Cheng, yan(chengyan@pku.edu.cn) |
| 英文摘要 | The combination of graphene oxide (go) with robust mechanical property, silk fibroin (sf) with fascinating biological effects and hydroxyapatite (ha) with superior osteogenic activity is a competitive approach to make novel coatings for orthopedic applications. herein, the feasibility of depositing ternary sf/go/ha nanocomposite coatings on ti substrate was firstly verified by exploiting electrophoretic nanotechnology, with sf being used as both a charging additive and a dispersion agent. the surface morphology, microstructure and composition, in vitro hemocompatibility and in vitro cytocompatibility of the resulting coatings were investigated by sem, raman, ftir spectra and biocompatibility tests. results demonstrated that go, ha and sf could be co-deposited with a uniform, smooth thin-film morphology. the hemolysis rate analysis and the platelet adhesion test indicated good blood compatibility of the coatings. the human osteosarcoma mg63 cells displayed well adhesion and proliferation behaviors on the prepared coatings, with enhanced alp activities. the present study suggested that sf/go/ha nanocomposite coatings could be a promising candidate for the surface functionalization of biomaterials, especially as orthopedic implant coating. |
| WOS关键词 | MESENCHYMAL STEM-CELLS ; GRAPHENE OXIDE ; CARDIOMYOGENIC DIFFERENTIATION ; OSTEOGENIC DIFFERENTIATION ; PROTEIN SCAFFOLDS ; DENTAL IMPLANTS ; FIBROIN ; HYDROXYAPATITE ; COMPOSITE ; DELIVERY |
| WOS研究方向 | Materials Science |
| WOS类目 | Materials Science, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000381204000004 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375005 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Mo, Maosong; Cheng, Yan |
| 作者单位 | 1.Chinese Acad Sci, Inst Elect Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Elect Elect & Commun Engn, Beijing 100049, Peoples R China 3.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China 4.Peking Univ, Dept Mat Sci & Engn, Coll Engn, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ming,Xiong, Pan,Mo, Maosong,et al. Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications[J]. Frontiers of materials science,2016,10(3):270-280. |
| APA | Li, Ming,Xiong, Pan,Mo, Maosong,Cheng, Yan,&Zheng, Yufeng.(2016).Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications.Frontiers of materials science,10(3),270-280. |
| MLA | Li, Ming,et al."Electrophoretic-deposited novel ternary silk fibroin/graphene oxide/hydroxyapatite nanocomposite coatings on titanium substrate for orthopedic applications".Frontiers of materials science 10.3(2016):270-280. |
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来源：中国科学院大学
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