Mers-cov spike protein: targets for vaccines and therapeutics
文献类型：期刊论文
| 作者 | Wang, Qihui1,2; Wong, Gary2,3,4; Lu, Guangwen5,6; Yan, Jinghua1,2,3,7; Gao, George F.2,3,4,7,8,9,10 |
| 刊名 | Antiviral research
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 133页码:165-177 |
| 关键词 | Coronavirus Mers-cov Spike protein Vaccines Therapeutics Animal models |
| ISSN号 | 0166-3542 |
| DOI | 10.1016/j.antiviral.2016.07.015 |
| 通讯作者 | Wang, qihui(wangqihui@im.ac.cn) ; Gao, george f.(gaof@im.ac.cn) |
| 英文摘要 | The disease outbreak caused by middle east respiratory syndrome coronavirus (mers-cov) is still ongoing in the middle east. over 1700 people have been infected since it was first reported in september 2012. despite great efforts, licensed vaccines or therapeutics against mers-cov remain unavailable. the mers-cov spike (s) protein is an important viral antigen known to mediate host-receptor binding and virus entry, as well as induce robust humoral and cell-mediated responses in humans during infection. in this review, we highlight the importance of the s protein in the mers-cov life cycle, summarize recent advances in the development of vaccines and therapeutics based on the s protein, and discuss strategies that can be explored to develop new medical countermeasures against mers-cov. (c) 2016 elsevier b.v. all rights reserved. |
| WOS关键词 | EAST RESPIRATORY SYNDROME ; RECEPTOR-BINDING DOMAIN ; MEMBRANE-FUSION PROTEINS ; PAPAIN-LIKE PROTEASE ; SYNDROME CORONAVIRUS INFECTION ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; TO-HUMAN TRANSMISSION ; MIDDLE-EAST ; NEUTRALIZING ANTIBODIES ; SAUDI-ARABIA |
| WOS研究方向 | Pharmacology & Pharmacy ; Virology |
| WOS类目 | Pharmacology & Pharmacy ; Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000384856200019 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375014 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Qihui; Gao, George F. |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Microbial Physiol & Metab Engn, Beijing 100101, Peoples R China 2.Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen 518112, Peoples R China 3.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 4.Chinese Acad Sci, CAS Ctr Influenza Res & Early Warning CASCIRE, Beijing 100101, Peoples R China 5.Sichuan Univ, West China Hosp, State Key Lab Biotherapy, WCHED, Chengdu 610041, Sichuan, Peoples R China 6.Sichuan Univ, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Sichuan, Peoples R China 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 8.Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China 9.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China 10.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qihui,Wong, Gary,Lu, Guangwen,et al. Mers-cov spike protein: targets for vaccines and therapeutics[J]. Antiviral research,2016,133:165-177. |
| APA | Wang, Qihui,Wong, Gary,Lu, Guangwen,Yan, Jinghua,&Gao, George F..(2016).Mers-cov spike protein: targets for vaccines and therapeutics.Antiviral research,133,165-177. |
| MLA | Wang, Qihui,et al."Mers-cov spike protein: targets for vaccines and therapeutics".Antiviral research 133(2016):165-177. |
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来源：中国科学院大学
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