Dual ph and oxidation-responsive nanogels crosslinked by diselenide bonds for controlled drug delivery
文献类型：期刊论文
| 作者 | Cheng, Xinfeng1,2; Jin, Yong3,4; Qi, Rui1,2; Fan, Wuhou3,4; Li, Hanping3,4; Sun, Xiaopeng3,4; Lai, Shuangquan3,4 |
| 刊名 | Polymer
 |
| 出版日期 | 2016-09-28 |
| 卷号 | 101页码:370-378 |
| 关键词 | Nanogel Core-crosslinking Ph-responsive Oxidation -responsive Drug delivery |
| ISSN号 | 0032-3861 |
| DOI | 10.1016/j.polymer.2016.08.087 |
| 通讯作者 | Jin, yong(jinyong@cioc.ac.cn) |
| 英文摘要 | A new diselenide crosslinked polyurethane nanogel was developed, which could respond to ph change and oxidaiton condition. firstly, pegylated polyurethane (mpeg-pubm-mpeg) containing tertiary amino and br groups was prepared, which can assemble into micelles in aqueous solution. then the nanogels with diselenides crosslinked polyurethane (pu) core and hydrophilic peg shell were prepared using sodium diselenide (na2se2) as a crosslinking agent to react with the br groups in the pubm block. the resultant nanogels exhibited enhanced colloidal stability relative to the non-crosslinked micelles, which have a spherical morphology with a diameter about 110-120 nm. interestingly, the nanogels displayed a ph-induced swelling and oxidation-triggered dissociation behaviors, which can efficiently load indomethacin (ind) drugs and showed an inhibited premature release behavior as compared to the non-crosslinked micelles. an accelerated release behavior at ph 5.0 (54% in 24 h) and a burst release under oxidation condition (95% in 20 h) were observed for the nanogels, indicating their dual ph and oxidation-triggered release behaviors. considering their enhanced stability, ph-induced swelling and oxidation-triggered degradation characteristics, the diselenide crosslinked nanogels can serve as a potential system for controlled drug delivery. (c) 2016 elsevier ltd. all rights reserved. |
| WOS关键词 | POLYMER MICELLES ; ANTICANCER AGENT ; CANCER-THERAPY ; RELEASE ; REDOX ; CORE ; NANOPARTICLES ; DOXORUBICIN ; STABILITY ; POLYURETHANES |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000384784800040 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375030 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Jin, Yong |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Ctr Polymer Sci & Technol, Chengdu 610041, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Sichuan Univ, Natl Engn Lab Clean Technol Leather Mfg, Chengdu 610065, Peoples R China 4.Sichuan Univ, Key Lab Leather Chem & Engn, Minist Educ, Chengdu 610065, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, Xinfeng,Jin, Yong,Qi, Rui,et al. Dual ph and oxidation-responsive nanogels crosslinked by diselenide bonds for controlled drug delivery[J]. Polymer,2016,101:370-378. |
| APA | Cheng, Xinfeng.,Jin, Yong.,Qi, Rui.,Fan, Wuhou.,Li, Hanping.,...&Lai, Shuangquan.(2016).Dual ph and oxidation-responsive nanogels crosslinked by diselenide bonds for controlled drug delivery.Polymer,101,370-378. |
| MLA | Cheng, Xinfeng,et al."Dual ph and oxidation-responsive nanogels crosslinked by diselenide bonds for controlled drug delivery".Polymer 101(2016):370-378. |
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来源：中国科学院大学
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