Ugi reaction of natural amino acids: a general route toward facile synthesis of polypeptoids for bioapplications
文献类型：期刊论文
| 作者 | Zhang, Xiaojie1; Wang, Shixue1,3; Liu, Jing1; Xie, Zhigang2; Luan, Shifang2; Xiao, Chunsheng1; Tao, Youhua1; Wang, Xianhong1 |
| 刊名 | Acs macro letters
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 5期号:9页码:1049-1054 |
| ISSN号 | 2161-1653 |
| DOI | 10.1021/acsmacrolett.6b00530 |
| 通讯作者 | Tao, youhua(youhua.tao@ciac.ac.cn) ; Wang, xianhong(xhwang@ciac.ac.cn) |
| 英文摘要 | Polypeptoids represent a significant class of synthetic analogues of natural polypeptides with potential biomimetic applications in materials, catalysis, and pharmaceuticals, but their simple and general synthesis still remains a key challenge. herein, we demonstrate that ugi reaction of natural amino acids leads to structurally diverse polypeptoids, including gamma- and delta-, as well as poly(epsilon-peptoid)s, under mild conditions (open to air, room temperature, and catalyst free). moreover, this strategy also offers manifold opportunities to introduce functional groups such as fluorescent and clickable alkenes groups into polypeptoids. such poly(epsilon-peptoid)s not only exhibit good biocompatibility and antibacterial activity, but perform very effectively as a drug-delivery system. the bacterial inhibition rate of poly(epsilon-peptoid) was up to 88.8% at concentration of 20 mu g ml(-1) in comparison to 61.8% of the poly(epsilon-lysine) control. overall, this study offers us a general methodology toward facile preparation of polypeptoids for bioapplications |
| WOS关键词 | RING-OPENING POLYMERIZATION ; MEDIATED ZWITTERIONIC POLYMERIZATION ; N-CARBOXYANHYDRIDE POLYMERIZATION ; SOLID-PHASE SYNTHESIS ; POLY-BETA-PEPTOIDS ; BIOMEDICAL APPLICATIONS ; 4-COMPONENT REACTION ; RAFT POLYMERIZATION ; BLOCK-COPOLYMERS ; CARBON-MONOXIDE |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000384041100012 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375044 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tao, Youhua; Wang, Xianhong |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, 5625 Renmin St, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaojie,Wang, Shixue,Liu, Jing,et al. Ugi reaction of natural amino acids: a general route toward facile synthesis of polypeptoids for bioapplications[J]. Acs macro letters,2016,5(9):1049-1054. |
| APA | Zhang, Xiaojie.,Wang, Shixue.,Liu, Jing.,Xie, Zhigang.,Luan, Shifang.,...&Wang, Xianhong.(2016).Ugi reaction of natural amino acids: a general route toward facile synthesis of polypeptoids for bioapplications.Acs macro letters,5(9),1049-1054. |
| MLA | Zhang, Xiaojie,et al."Ugi reaction of natural amino acids: a general route toward facile synthesis of polypeptoids for bioapplications".Acs macro letters 5.9(2016):1049-1054. |
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来源：中国科学院大学
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