Selective synaptic remodeling of amygdalocortical connections associated with fear memory
文献类型：期刊论文
| 作者 | Yang, Yang1; Liu, Dan-qian1,2; Huang, Wei1,4; Deng, Juan1,2; Sun, Yangang1; Zuo, Yi3; Poo, Mu-ming1 |
| 刊名 | Nature neuroscience
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 19期号:10页码:1348-+ |
| ISSN号 | 1097-6256 |
| DOI | 10.1038/nn.4370 |
| 通讯作者 | Yang, yang(yangyang@ion.ac.cn) |
| 英文摘要 | Neural circuits underlying auditory fear conditioning have been extensively studied. here we identified a previously unexplored pathway from the lateral amygdala (la) to the auditory cortex (acx) and found that selective silencing of this pathway using chemo-and optogenetic approaches impaired fear memory retrieval. dual-color in vivo two-photon imaging of mouse acx showed pathway-specific increases in the formation of la axon boutons, dendritic spines of acx layer 5 pyramidal cells, and putative la-acx synaptic pairs after auditory fear conditioning. furthermore, joint imaging of pre- and postsynaptic structures showed that essentially all new synaptic contacts were made by adding new partners to existing synaptic elements. together, these findings identify an amygdalocortical projection that is important to fear memory expression and is selectively modified by associative fear learning, and unravel a distinct architectural rule for synapse formation in the adult brain. |
| WOS关键词 | PRIMARY AUDITORY-CORTEX ; DENDRITIC SPINES ; STRUCTURAL PLASTICITY ; ADULT NEOCORTEX ; THALAMIC INPUT ; LONG-RANGE ; IN-VIVO ; CIRCUITS ; SYNAPSES ; BRAIN |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000384549900015 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375057 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, Yang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci,State Key Lab Neurosci, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Inst Neurosci, Beijing, Peoples R China 3.Univ Calif Santa Cruz, Dept Mol Cell & Dev Biol, Santa Cruz, CA 95064 USA 4.Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA |
| 推荐引用方式 GB/T 7714 | Yang, Yang,Liu, Dan-qian,Huang, Wei,et al. Selective synaptic remodeling of amygdalocortical connections associated with fear memory[J]. Nature neuroscience,2016,19(10):1348-+. |
| APA | Yang, Yang.,Liu, Dan-qian.,Huang, Wei.,Deng, Juan.,Sun, Yangang.,...&Poo, Mu-ming.(2016).Selective synaptic remodeling of amygdalocortical connections associated with fear memory.Nature neuroscience,19(10),1348-+. |
| MLA | Yang, Yang,et al."Selective synaptic remodeling of amygdalocortical connections associated with fear memory".Nature neuroscience 19.10(2016):1348-+. |
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来源：中国科学院大学
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