Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma
文献类型：期刊论文
| 作者 | Zhang, Bao1,2,3; Wang, Dongpeng1,2,3; Wu, Jing4; Tang, Jun5; Chen, Weixiong5; Chen, Xiaomin1,2; Zhang, Dongdong1,2; Deng, Yanming4; Guo, Mingzhou6; Wang, Yuejian5 |
| 刊名 | Discovery medicine
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 21期号:116页码:239-250 |
| ISSN号 | 1539-6509 |
| 通讯作者 | Wang, yuejian(wyjian@fsyyy.com) ; Luo, jianjun(luojianj@moon.ibp.ac.cn) ; Chen, runsheng(rschen@ibp.ac.cn) |
| 英文摘要 | Rapidly growing evidence has shown that long noncoding rnas (lncrnas) are playing more and more important roles in a variety of biological processes and have been involved in various types of cancer. how to better decode these noncoding transcripts and how to predict their potential roles in tumorigenesis particularly in nasopharyngeal carcinoma (npc) are still open questions. in this study, we applied our custom-designed lncrna+mrna gene expression microarray, which contains probes against 38,141 lncrna transcripts, to assaying the expression profiling of flash-frozen tumorous and non-tumorous tissue samples from nonkeratinizing carcinoma (nkc), which is the major histologic type of npc. as a result, 481 differentially expressed (de) lncrnas (231 up-regulated and 250 down-regulated) were identified. moreover, integrated bioinformatics analyses including gene ontology, lncrna functional prediction based on coding-noncoding gene co-expression network, interactive mirnas, and transcription factor binding motifs were all carried out to decode the potential functional roles of these newly identified de-lncrnas. this work hence offers new resource and insight into lncrnas for further understanding the molecular mechanisms of tumorigenesis of nkc, and may also define new biomarkers or therapy targets for the translational studies of nkc. |
| WOS关键词 | GENE COEXPRESSION NETWORK ; TRANSCRIPTION ; CANCER ; PROGRESSION ; ACTIVATION ; CHROMATIN ; MARKER ; LNCRNA ; CELLS |
| WOS研究方向 | Research & Experimental Medicine |
| WOS类目 | Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000376677700002 |
| 出版者 | DISCOVERY MEDICINE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375075 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Yuejian; Luo, Jianjun; Chen, Runsheng |
| 作者单位 | 1.Chinese Acad Sci, Key Lab RNA Biol, Inst Biophys, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Beijing Key Lab Noncoding RNA, Inst Biophys, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.First Peoples Hosp Foshan, Canc Ctr, Foshan 528000, Guangdong, Peoples R China 5.First Peoples Hosp Foshan, Dept Otolaryngol, Foshan 528000, Guangdong, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Bao,Wang, Dongpeng,Wu, Jing,et al. Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma[J]. Discovery medicine,2016,21(116):239-250. |
| APA | Zhang, Bao.,Wang, Dongpeng.,Wu, Jing.,Tang, Jun.,Chen, Weixiong.,...&Chen, Runsheng.(2016).Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma.Discovery medicine,21(116),239-250. |
| MLA | Zhang, Bao,et al."Expression profiling and functional prediction of long noncoding rnas in nasopharyngeal nonkeratinizing carcinoma".Discovery medicine 21.116(2016):239-250. |
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来源：中国科学院大学
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