"manganese extraction" strategy enables tumor-sensitive biodegradability and theranostics of nanoparticles
文献类型：期刊论文
| 作者 | Yu, Luodan1,2; Chen, Yu1; Wu, Meiying1,2; Cai, Xiaojun1,2; Yao, Heliang1; Zhang, Linlin1; Chen, Hangrong1; Shi, Jianlin1 |
| 刊名 | Journal of the american chemical society
 |
| 出版日期 | 2016-08-10 |
| 卷号 | 138期号:31页码:9881-9894 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/jacs.6b04299 |
| 通讯作者 | Chen, yu(chenyu@mail.sic.ac.cn) ; Chen, hangrong(hrchen@mail.sic.ac.cn) ; Shi, jianlin(jlshi@mail.sic.ac.cn) |
| 英文摘要 | Biodegradability of inorganic nanoparticles is one of the most critical issues in their further clinical translations. in this work, a novel "metal ion-doping" approach has been developed to endow inorganic mesoporous silica-based nanoparticles with tumor-sensitive biodegradation and theranostic functions, simply by topological transformation of mesoporous silica to metal-doped composite nanoformulations. "manganese extraction" sensitive to tumor microenvironment was enabled in manganese-doped hollow mesoporous silica nanoparticles (designated as mn-hmsns) to fast promote the disintegration and biodegradation of mn-hmsns, further accelerating the breakage of si o si bonds within the framework. the fast biodegradation of mn-hmsns sensitive to mild acidic and reducing microenvironment of tumor resulted in much accelerated anticancer drug releasing and enhanced ti-weighted magnetic resonance imaging of tumor. a high tumor-inhibition effect was simultaneously achieved by anticancer drug delivery mediated by pegylated mn-hmsns, and the high biocompatibility of composite nanosystems was systematically demonstrated in vivo. this is the first demonstration of biodegradable inorganic mesoporous nanosystems with specific biodegradation behavior sensitive to tumor microenvironment, which also provides a feasible approach to realize the on-demand biodegradation of inorganic nanomaterials simply by "metal ion-doping" strategy, paving the way to solve the critical low-biodegradation issue of inorganic drug carriers. |
| WOS关键词 | MESOPOROUS SILICA NANOPARTICLES ; ANTICANCER DRUG-DELIVERY ; RESPONSIVE CONTROLLED-RELEASE ; CANCER-CELLS ; BIOMEDICAL APPLICATIONS ; PLATFORM ; THERAPY ; SPHERES ; SYSTEM ; NANOCARRIERS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000381332300024 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375086 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Yu; Chen, Hangrong; Shi, Jianlin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Luodan,Chen, Yu,Wu, Meiying,et al. "manganese extraction" strategy enables tumor-sensitive biodegradability and theranostics of nanoparticles[J]. Journal of the american chemical society,2016,138(31):9881-9894. |
| APA | Yu, Luodan.,Chen, Yu.,Wu, Meiying.,Cai, Xiaojun.,Yao, Heliang.,...&Shi, Jianlin.(2016)."manganese extraction" strategy enables tumor-sensitive biodegradability and theranostics of nanoparticles.Journal of the american chemical society,138(31),9881-9894. |
| MLA | Yu, Luodan,et al.""manganese extraction" strategy enables tumor-sensitive biodegradability and theranostics of nanoparticles".Journal of the american chemical society 138.31(2016):9881-9894. |
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来源：中国科学院大学
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