Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid beta-peptide aggregation
文献类型：期刊论文
| 作者 | Li, Meng1,2,3; Guan, Yijia1,2,3; Chen, Zhaowei1,2,3; Gao, Nan1,2; Ren, Jinsong1,2; Dong, Kai1,2,3; Qu, Xiaogang1,2 |
| 刊名 | Nano research
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 9期号:8页码:2411-2423 |
| 关键词 | Amyloid disease Platinum Graphitic carbon nitride nanosheet Photooxygenation Amyloid beta-peptide (a beta) inhibitors |
| ISSN号 | 1998-0124 |
| DOI | 10.1007/s12274-016-1127-5 |
| 通讯作者 | Qu, xiaogang(xqu@ciac.ac.cn) |
| 英文摘要 | Amyloid beta-peptide (a beta) aggregation is a critical step in the pathogenesis of alzheimer's disease (ad). inhibition of a beta production, dissolution of existing aggregates and clearance of a beta represent valid therapeutic strategies against ad. herein, a novel platinum(ii)-coordinated graphitic carbon nitride (g-c3n4) nanosheet (g-c3n4@pt) has been designed to covalently bind to a beta and modulate the peptide's aggregation and toxicity. furthermore, g-c3n4@pt nanosheets possess high photocatalytic activity and can oxygenate a beta upon visible light irradiation, remarkably attenuating both the aggregation potency and neurotoxicity of a beta. due to its ability to cross the blood-brain barrier (bbb) and its good biocompatibility, g-c3n4@pt nanosheet is a promising inhibitor of a beta aggregation. this study may serve as a model for the engineering of novel multifunctional nanomaterials used for the treatment of ad. |
| WOS关键词 | ALZHEIMERS-DISEASE ; FIBRIL FORMATION ; VISIBLE-LIGHT ; OLIGOMERS ; PROTEIN ; PERFORMANCE ; NANOPARTICLES ; MODEL ; PROBE ; PHOTODEGRADATION |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000380726200020 |
| 出版者 | TSINGHUA UNIV PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375088 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Qu, Xiaogang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Meng,Guan, Yijia,Chen, Zhaowei,et al. Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid beta-peptide aggregation[J]. Nano research,2016,9(8):2411-2423. |
| APA | Li, Meng.,Guan, Yijia.,Chen, Zhaowei.,Gao, Nan.,Ren, Jinsong.,...&Qu, Xiaogang.(2016).Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid beta-peptide aggregation.Nano research,9(8),2411-2423. |
| MLA | Li, Meng,et al."Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid beta-peptide aggregation".Nano research 9.8(2016):2411-2423. |
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来源：中国科学院大学
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