Zika virus disrupts neural progenitor development and leads to microcephaly in mice
文献类型：期刊论文
| 作者 | Li, Cui1,2; Xu, Dan5; Ye, Qing2,3; Hong, Shuai1; Jiang, Yisheng1,2; Liu, Xinyi1; Zhang, Nana3,6; Shi, Lei1; Qin, Cheng-Feng3; Xu, Zhiheng1,4 |
| 刊名 | Cell stem cell
 |
| 出版日期 | 2016-07-07 |
| 卷号 | 19期号:1页码:120-126 |
| ISSN号 | 1934-5909 |
| 通讯作者 | Qin, cheng-feng(qincf@bmi.ac.cn) ; Xu, zhiheng(zhxu@genetics.ac.cn) |
| 英文摘要 | The link between zika virus (zikv) infection and microcephaly has raised urgent global alarm. the historical african zikv mr766 was recently shown to infect cultured human neural precursor cells (npcs), but unlike the contemporary zikv strains, it is not believed to cause microcephaly. here we investigated whether the asian zikv strain sz01 could infect npcs in vivo and affect brain development. we found that sz01 replicates efficiently in embryonic mouse brain by directly targeting different neuronal linages. zikv infection leads to cell-cycle arrest, apoptosis, and inhibition of npc differentiation, resulting in cortical thinning and microcephaly. global gene expression analysis of infected brains reveals upregulation of candidate flavirus entry receptors and dysregulation of genes associated with immune response, apoptosis, and microcephaly. our model provides evidence for a direct link between zika virus infection and microcephaly, with potential for further exploration of the underlying mechanisms and management of zikv-related pathological effects during brain development. |
| WOS关键词 | CELLS ; STEM |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell & Tissue Engineering ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000381620500016 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375152 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Qin, Cheng-Feng; Xu, Zhiheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100101, Peoples R China 3.Beijing Inst Microbiol & Epidemiol, Dept Virol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China 4.Beijing Inst Brain Disorders, Parkinsons Dis Ctr, Beijing 100101, Peoples R China 5.Fuzhou Univ, Inst Life Sci, Fuzhou 350116, Peoples R China 6.Guangxi Med Univ, Nanning 530021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Cui,Xu, Dan,Ye, Qing,et al. Zika virus disrupts neural progenitor development and leads to microcephaly in mice[J]. Cell stem cell,2016,19(1):120-126. |
| APA | Li, Cui.,Xu, Dan.,Ye, Qing.,Hong, Shuai.,Jiang, Yisheng.,...&Xu, Zhiheng.(2016).Zika virus disrupts neural progenitor development and leads to microcephaly in mice.Cell stem cell,19(1),120-126. |
| MLA | Li, Cui,et al."Zika virus disrupts neural progenitor development and leads to microcephaly in mice".Cell stem cell 19.1(2016):120-126. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。