Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells
文献类型：期刊论文
| 作者 | Fu, Jing-Peng1,3; Mo, Wei-Chuan1,2; Liu, Ying1,3; Bartlett, Perry F.2; He, Rong-Qiao1,3,4 |
| 刊名 | Protein & cell
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 7期号:9页码:624-637 |
| 关键词 | Hypomagnetic field Neural progenitor/stem cells Neurosphere Proliferation Stemness Multipotency |
| ISSN号 | 1674-800X |
| DOI | 10.1007/s13238-016-0300-7 |
| 通讯作者 | Liu, ying(yingliu@ibp.ac.cn) ; He, rong-qiao(herq@sun5.ibp.ac.cn) |
| 英文摘要 | Living organisms are exposed to the geomagnetic field (gmf) throughout their lifespan. elimination of the gmf, resulting in a hypogeomagnetic field (hmf), leads to central nervous system dysfunction and abnormal development in animals. however, the cellular mechanisms underlying these effects have not been identified so far. here, we show that exposure to an hmf (< 200 nt), produced by a magnetic field shielding chamber, promotes the proliferation of neural progenitor/stem cells (npcs/nscs) from c57bl/6 mice. following seven-day hmf-exposure, the primary neurospheres (nss) were significantly larger in size, and twice more npcs/nscs were harvested from neonatal nss, when compared to the gmf controls. the self-renewal capacity and multipotency of the nss were maintained, as hmf-exposed nss were positive for nsc markers (nestin and sox2), and could differentiate into neurons and astrocyte/glial cells and be passaged continuously. in addition, adult mice exposed to the hmf for one month were observed to have a greater number of proliferative cells in the subventricular zone. these findings indicate that continuous hmf-exposure increases the proliferation of npcs/nscs, in vitro and in vivo. hmf-disturbed npcs/nscs production probably affects brain development and function, which provides a novel clue for elucidating the cellular mechanisms of the bio-hmf response. |
| WOS关键词 | FREQUENCY MAGNETIC-FIELDS ; HUMAN NEUROBLASTOMA-CELLS ; HYPOMAGNETIC FIELD ; SELF-RENEWAL ; DROSOPHILA-MELANOGASTER ; NERVOUS-SYSTEM ; RADICAL PAIR ; BRAIN ; EXPOSURE ; GROWTH |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000382669000002 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2375163 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Ying; He, Rong-Qiao |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Jing-Peng,Mo, Wei-Chuan,Liu, Ying,et al. Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells[J]. Protein & cell,2016,7(9):624-637. |
| APA | Fu, Jing-Peng,Mo, Wei-Chuan,Liu, Ying,Bartlett, Perry F.,&He, Rong-Qiao.(2016).Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells.Protein & cell,7(9),624-637. |
| MLA | Fu, Jing-Peng,et al."Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and stem cells".Protein & cell 7.9(2016):624-637. |
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来源：中国科学院大学
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